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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제45권 제3호
발행연도
2013.1
수록면
210 - 219 (10page)

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Purpose Inflammation within the tumor microenvironment has been reported to show an association with poor prognosis in breast cancer. However, the associations may differ according to breast cancer subtype. In this study, we investigated the association between inflammation-related markers and breast cancer recurrence according to patients’ tumor subtypes. Materials and Methods This prospective study included 240 patients who underwent surgery for management of newly diagnosed breast cancer. Levels of inflammation-related markers (interleukin [IL]-1β, IL-6, IL-8, monocyte chemoattractant protein-1 [MCP-1], leptin, and adiponectin)were measured at diagnosis, and the associations between these markers and breast cancer recurrence during a six-year follow-up period were examined using the Kaplan-Meier statistical method. Results Overall, inflammation-related markers showed no association with breast cancer recurrence. However, when data were stratified by tumor subtype, higher levels of some mediators showed an association with poor prognosis among patients with particular subtypes. Compared to patients without recurrence, patients with recurrence had higher levels of circulating IL-6 (p=0.024) and IL-8 (p=0.016) only among those with HER2– tumors and had higher levels of leptin (p=0.034) only among those with estrogen receptor (ER)+/progesterone receptor (PR)+ tumors. Results of survival analyses revealed an association of high levels of IL-6 (p=0.016) and IL-8 (p=0.022)with poor recurrence-free survival in patients with HER2– tumors. In addition, higher leptin levels indicated shorter recurrence-free survival time only among patients with ER+/PR+ tumors (p=0.022). Conclusion We found that certain cytokines could have a differential prognostic impact on breast cancer recurrence according to breast cancer subtype. Conduct of additional large studies will be required in order to elucidate the precise roles of these cytokines in breast cancer progression.
#Breast neoplasms #Recurrence #Cytokines #HER2 #Estrogen receptors #Progesterone receptors

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참고문헌 (24)

참고문헌 신청
Bachelot T / 2003 / Prognostic value of serum levels of interleukin 6 and of serum and plasma levels of vascular endothelial growth factor in hormone-refractory metastatic b google schola Barone I / 2012 / Leptin mediates tumor-stromal interactions that promote the invasive growth of breast cancer cells / Cancer Res 72 : 1416 ~ 1427 google schola Benoy IH / 2004 / Increased serum interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival / Clin Cancer Res 10 : 7 google schola Catalano S / 2003 / Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line / J Biol Chem 278 : 28668 ~ 28676 google schola Catalano S / 2004 / Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells / J Biol Chem 279 : 19908 ~ 19915 google schola

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