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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 37 - 44 (8page)
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초록· 키워드
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Purpose The aim of this study was to evaluate outcomes of hypofractionated stereotactic radiation therapy (HSRT) in patients re-treated for recurrent high-grade glioma.
Materials and Methods From January 2006 to September 2013, 25 patients were treated. Six patients underwent radiation therapy alone, while 19 underwent combined treatment with surgery and/or chemotherapy. Only patients with Karnofsky Performance Status (KPS) > 70 and time from previous radiotherapy greater than 6 months were re-irradiated. The mean recurrent tumor volume was 35 cm3 (range, 2.46 to 116.7 cm3), and most of the patients (84%) were treated with a total dose of 25 Gy in five fractions (range, 20 to 50 Gy in 5-10 fractions).
Results The median follow-up was 18 months (range, 4 to 36 months). The progression-free survival (PFS) at 1 and 2 years was 72% and 34% and the overall survival (OS) 76% and 50%, respectively. No severe toxicity was recorded. In univariate and multivariate analysis extent of resection at diagnosis significantly influenced PFS and OS (p < 0.01). Patients with smaller recurrent tumor volume treated had better local control and survival. Indeed, the 2-year PFS was 40% (! 50 cm3) versus 11% (p=0.1) and the 2-year OS 56% versus 33% (> 50 cm3), respectively (p=0.26).
Conclusion In our experience, HSRT could be a safe and feasible therapeutic option for recurrent high grade glioma even in patients with larger tumors. We believe that a multidisciplinary evalu- ation is mandatory to assure the best treatment for selected patients. Local treatment should also be considered as part of an integrated approach.
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참고문헌 (25)
참고문헌 신청
Stupp R / 2009 / Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study : 5-year analysis of the EORTC-NCIC trial / Lancet Oncol 10:459~466
National Comprehensive Cancer Network / NCCN guidelines:central nervous system cancers 2012
Minniti G / 2010 / Patterns of failure and comparison of different target volume delineations in patients with glioblastoma treated with conformal radiotherapy plus concomitant and adjuvant temozolomide / Radiother Oncol 97:377~381
Garden AS / 1991 / Outcome and patterns of failure following limitedvolume irradiation for malignant astrocytomas / Radiother Oncol 20:99~110
Hess CF / 1994 / Malignant glioma : patterns of failure following individually tailored limited volume irradiation / Radiother Oncol 30:146~149
National Comprehensive Cancer Network / NCCN guidelines:central nervous system cancers 2012
Minniti G / 2010 / Patterns of failure and comparison of different target volume delineations in patients with glioblastoma treated with conformal radiotherapy plus concomitant and adjuvant temozolomide / Radiother Oncol 97:377~381
Garden AS / 1991 / Outcome and patterns of failure following limitedvolume irradiation for malignant astrocytomas / Radiother Oncol 20:99~110
Hess CF / 1994 / Malignant glioma : patterns of failure following individually tailored limited volume irradiation / Radiother Oncol 30:146~149
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