지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,274 - 1,285 (12page)
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초록· 키워드
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Purpose The purpose of this study is to assess the role of adjuvant therapy in stage I-III gallbladder cancer (GBC) patients who have undergone R0 resection.
Materials and Methods Clinical data were collected on 441 consecutive patients who underwent R0 resection for stage I-III GBC. Eligible patients were classified into adjuvant therapy and surveillance only groups. Propensity score matching (PSM) between the two groups was performed, adjusting clinical factors.
Results In total, 84 and 279 patients treated with adjuvant therapy and followed up with surveillance only, respectively, were included in the analysis. Before PSM, the 5-year relapse-free survival (RFS) rate was lower in the adjuvant therapy group than in the surveillance only group (50.8% vs. 74.8%, p < 0.001), although there was no statistically significant difference in the 5-year overall survival (OS) rate (66.2% vs. 79.5%, p=0.089). After the PSM, baseline characteristics became comparable and there were no differences in the 5-year RFS (50.8% vs. 64.8%, p=0.319) and OS (66.2% vs. 70.4%, p=0.703) rates between the two groups.
Conclusion The results suggest that fluoropyrimidine-based adjuvant therapy is not indicated in stage I-III GBC patients who have undergone R0 resection.
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참고문헌 (22)
참고문헌 신청
Siegel RL / 2015 / Cancer statistics, 2015 / CA Cancer J Clin 65:5~29
정규원 / 2015 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2012 / Cancer Research and Treatment 47(2):127~141
Lim H / 2013 / Prognostic factors in patients with gallbladder cancer after surgical resection : analysis of 279 operated patients / J Clin Gastroenterol 47:443~448
Gold DG / 2009 / Adjuvant therapy for gallbladder carcinoma : the Mayo Clinic Experience / Int J Radiat Oncol Biol Phys 75:150~155
Wang SJ / 2008 / Prediction model for estimating the survival benefit of adjuvant radiotherapy for gallbladder cancer / J Clin Oncol 26:2112~2117
정규원 / 2015 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2012 / Cancer Research and Treatment 47(2):127~141
Lim H / 2013 / Prognostic factors in patients with gallbladder cancer after surgical resection : analysis of 279 operated patients / J Clin Gastroenterol 47:443~448
Gold DG / 2009 / Adjuvant therapy for gallbladder carcinoma : the Mayo Clinic Experience / Int J Radiat Oncol Biol Phys 75:150~155
Wang SJ / 2008 / Prediction model for estimating the survival benefit of adjuvant radiotherapy for gallbladder cancer / J Clin Oncol 26:2112~2117
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