지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,373 - 1,381 (9page)
이용수
초록· 키워드
오류제보하기
Purpose The purpose of this study is to investigate the prognostic value of lymph node (LN) ratio (LNR) in patients with breast cancer after neoadjuvant chemotherapy.
Materials and Methods This retrospective analysis is based on the data of 814 patients with stage II/III breast cancer treated with four cycles of doxorubicin/cyclophosphamide followed by four cycles of docetaxel before surgery. We evaluated the clinical significance of LNR (3 categories: low 0-0.20 vs. intermediate 0.21-0.65 vs. high 0.66-1.00) using a Cox proportional regression model.
Results A total of 799 patients underwent breast surgery. Pathologic complete response (pCR, ypT0/isN0) was achieved in 129 patients (16.1%) (hormone receptor [HR] +/human epidermal growth factor receptor 2 [HER2] –, 34/373 [9.1%]; HER2+, 45/210 [21.4%]; triple negative breast cancer, 50/216 [23.1%]). The mean numbers of involved LN and retrieved LN were 2.70 (range, 0 to 42) and 13.98 (range, 1 to 64), respectively. The mean LNR was 0.17 (low, 574 [71.8%]; intermediate, 170 [21.3%]; high, 55 [6.9%]). In univariate analysis, LNR showed significant association with a worse relapse-free survival (3-year relapse-free survival rate 84.8% in low vs. 66.2% in intermediate vs. 54.3% in high; p < 0.001, log-rank test). In multivariate analysis, LNR did not show significant association with recurrence after adjusting for other clinical factors (age, histologic grade, subtype, ypT stage, ypN stage, lymphatic or vascular invasion, and pCR). In subgroup analysis, the LNR system had good prognostic value in HR+/HER2– subtype.
Conclusion LNR is not superior to ypN stage in predicting clinical outcome of breast cancer after neoadjuvant chemotherapy. However, the prognostic value of the LNR system in HR+/HER2– patients is notable and worthy of further investigation.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Fisher B / 1998 / Effect of preoperative chemotherapy on the outcome of women with operable breast cancer / J Clin Oncol 16:2672~2685
Bear HD / 2006 / Sequential preoperative or postoperative docetaxel added to preoperative doxorubicin plus cyclophosphamide for operable breast cancer : National Surgical Adjuvant Breast and Bowel Project Protocol B-27 / J Clin Oncol 24:2019~2027
van der Hage JA / 2001 / Preoperative chemotherapy in primary operable breast cancer : results from the European Organization for Research and Treatment of Cancer trial 10902 / J Clin Oncol 19:4224~4237
Cortazar P / 2014 / Pathological complete response and longterm clinical benefit in breast cancer : the CTNeoBC pooled analysis / Lancet 384:164~172
Kuerer HM / 1998 / Residual metastatic axillary lymph nodes following neoadjuvant chemotherapy predict disease-free survival in patients with locally advanced breast cancer / Am J Surg 176:502~509
Bear HD / 2006 / Sequential preoperative or postoperative docetaxel added to preoperative doxorubicin plus cyclophosphamide for operable breast cancer : National Surgical Adjuvant Breast and Bowel Project Protocol B-27 / J Clin Oncol 24:2019~2027
van der Hage JA / 2001 / Preoperative chemotherapy in primary operable breast cancer : results from the European Organization for Research and Treatment of Cancer trial 10902 / J Clin Oncol 19:4224~4237
Cortazar P / 2014 / Pathological complete response and longterm clinical benefit in breast cancer : the CTNeoBC pooled analysis / Lancet 384:164~172
Kuerer HM / 1998 / Residual metastatic axillary lymph nodes following neoadjuvant chemotherapy predict disease-free survival in patients with locally advanced breast cancer / Am J Surg 176:502~509
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effect of Neoadjuvant Chemotherapy on Axillary Lymph Node Positivity and Numbers in Breast Cancer Cases
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Prediction of Axillary Lymph Node Response Based on Breast Pathologic Complete Response and Breast Cancer Subtype after Neoadjuvant Chemotherapy
대한임상종양학회 학술대회지
2019 .02
-
Axillary Sampling as an Alternative Option for Complete Nodal Response in Triple Negative and HER2 Type Breast Cancer Patients after Neoadjuvant Chemotherapy
Journal of Breast Disease
2020 .01
-
Trends of axillary surgery in breast cancer patients with axillary lymph node metastasis: a comprehensive single-center retrospective study
Annals of Surgical Treatment and Research
2023 .07
-
Long Term Outcome in Patients with Nodal-positive Breast Cancer Treated with Sentinel Lymph Node Biopsy Alone after Neoadjuvant Chemotherapy
대한외과학회 학술대회 초록집
2022 .11
-
The Prognostic Value of Lymph Node Ratio after Neoadjuvant Chemotherapy in Patients with Locally Advanced Gastric Adenocarcinoma
Journal of Gastric Cancer
2021 .01
-
Lymph Node Ratio as a Good Prognostic Factor for Patients with Pathologic N3a Breast Cancer with 10 or More Metastatic Axillary Lymph Nodes
Journal of Breast Disease
2021 .12
-
Feasibility of Preoperative Axillary Lymph Node Marking with a Clip in Breast Cancer Patients before Neoadjuvant Chemotherapy : A Preliminary Study
대한외과학회 학술대회 초록집
2017 .11
-
[Breast] Prognosis of ypN1 After Sentinel Lymph Node Biopsy in Clinically Node Positive Breast Cancer Patients with Neoadjuvant Chemotherapy
대한외과학회 학술대회 초록집
2021 .11
-
Prognostic Value of Lymph Node Ratio in Pathologic N3a Breast Cancer Patients with Ten or More Metastatic Axillary Lymph Nodes
대한외과학회 학술대회 초록집
2021 .11
-
Lymph node ratio as a prognostic factor for pathologic N3a breast cancer patients with 10 or more metastatic axillary lymph nodes
대한외과학회 학술대회 초록집
2017 .11
-
Using the Lymph Node Ratio to Evaluate the Prognosis of Stage II/III Breast Cancer Patients Who Received Neoadjuvant Chemotherapy and Mastectomy
Cancer Research and Treatment
2015 .01
-
Prognostic effect of sentinel lymph node biopsy after neoadjuvant chemotherapy in cytologyproven, node-positive breast cancer
대한외과학회 학술대회 초록집
2017 .11
-
Sentinel Lymph Node Biopsy in Breast Cancer Patients With Pathological Complete Response in the Axillary Lymph Node After Neoadjuvant Chemotherapy
Journal of Breast Cancer
2021 .12
-
Predictive and Prognostic Roles of Pathological Indicators for Patients with Breast Cancer on Neoadjuvant Chemotherapy
Journal of Breast Cancer
2019 .01
-
The Role of Neoadjuvant Chemotherapy in Patients with ER Positive and HER2 Negative Breast Cancer
대한외과학회 학술대회 초록집
2018 .11
-
[Breast] MRI in the Prediction of Pathological Complete Response in Breast Cancer Patients after Neoadjuvant Chemotherapy
대한외과학회 학술대회 초록집
2022 .11
-
Feasibility of sentinel lymph node biopsy in patients who had conversion of axillary lymph nodes from clinically positive to negative following neoadjuvant chemotherapy
대한외과학회 학술대회 초록집
2017 .11
-
The Prognosis and the Role of Adjuvant Chemotherapy for Node-Positive Bladder Cancer Treated with Neoadjuvant Chemotherapy Followed by Surgery
Cancer Research and Treatment
2022 .01
-
The Optimal Treatment Strategy in Hormone Receptor-positive, Human Epidermal Growth Factor Receptor 2-negative Breast Cancer Patients with 1-2 Suspicious Axillary Lymph Node on Breast MRI: Upfront Surgery vs.Neoadjuvant Chemotherapy?
대한외과학회 학술대회 초록집
2022 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0