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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 551 - 561 (11page)
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Purpose Few studies for occult breast cancer (OBC) have evaluated the effect of radiotherapy (RT) after mastectomy or axillary lymph node dissection (ALND) with/without breast surgery. Therefore, we investigated clinicopathologic factors of OBC with the impact of postoperative RT to determine its prognostic significance using large population-based data. Materials and Methods We performed a retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) database from 1983 to 2013. A total of 1,045 eligible patients with OBC were identified. We compared overall survival (OS) using Cox proportional hazards regression with propensity score matching after verifying an imbalance of prognosticators between RT group (n=518) and non-RT group (n=479). Results Patients with age < 70 (p=0.033), married marital status (p < 0.001), undergoing ALND (p < 0.001), more examined lymph nodes (LNs) (p < 0.001), and more metastatic LNs (p < 0.001) were more likely to receive RT. Multivariate analysis after propensity score matching (n=798) showed that patients treated with RT survived significantly longer than those without RT (5-year OS, 81.5% vs. 78.3%; p=0.014). A significantly prolonged OS was observed when RT was given to patients treated with mastectomy (p=0.033), those treated with ALND (p=0.036), or those with more than seven metastatic LNs (p=0.016). Conclusion RT may offer survival benefit in OBC even after mastectomy or ALND, especially in patients with more than seven metastatic LNs. Further prospective studies are needed to validate these findings.
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참고문헌 (21)
참고문헌 신청
Patel J / 1981 / Axillary lymph node metastasis from an occult breast cancer / Cancer 47:2923~2927
Walker GV / 2010 / Population-based analysis of occult primary breast cancer with axillary lymph node metastasis / Cancer 116:4000~4006
National Comprehensive Cancer Network / 2016 / NCCN clinical practice guidelines in oncology, Breast cancer. v.2.2016 [Internet]
Masinghe SP / 2011 / Breast radiotherapy for occult breast cancer with axillary nodal metastases: does it reduce the local recurrence rate and increase overall survival? / Clin Oncol (R Coll Radiol) 23:95~100
He M / 2012 / Treatment outcomes and unfavorable prognostic factors in patients with occult breast cancer / Eur J Surg Oncol 38:1022~1028
Walker GV / 2010 / Population-based analysis of occult primary breast cancer with axillary lymph node metastasis / Cancer 116:4000~4006
National Comprehensive Cancer Network / 2016 / NCCN clinical practice guidelines in oncology, Breast cancer. v.2.2016 [Internet]
Masinghe SP / 2011 / Breast radiotherapy for occult breast cancer with axillary nodal metastases: does it reduce the local recurrence rate and increase overall survival? / Clin Oncol (R Coll Radiol) 23:95~100
He M / 2012 / Treatment outcomes and unfavorable prognostic factors in patients with occult breast cancer / Eur J Surg Oncol 38:1022~1028
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