지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 590 - 598 (9page)
이용수
초록· 키워드
오류제보하기
Purpose The treatment strategy for elderly patients older than 80 years with diffuse large B-cell lymphoma (DLBCL) has not been established because of poor treatment tolerability and lack of data. Materials and Methods This multicenter retrospective study was conducted to investigate clinical characteristics, treatment patterns and outcomes of patients older than 80 years who were diagnosed with DLBCL at 19 institutions in Korea between 2005 and 2016. Results A total of 194 patients were identified (median age, 83.3 years). Of these, 114 patients had an age-adjusted International Prognostic Index (aaIPI) score of 2-3 and 48 had a Charlson index score of 4 or more. R-CHOP was given in 124 cases, R-CVP in 13 cases, other chemotherapy in 17 cases, radiation alone in nine cases, and surgery alone in two cases. Twenty-nine patients did not undergo any treatment. The median number of chemotherapy cycles was three. Only 37 patients completed the planned treatment cycles. The overall response rate from 105 evaluable patients was 90.5% (complete response, 41.9%). Twentynine patients died due to treatment-related toxicities (TRT). Thirteen patients died due to TRT after the first cycle. Median overall survival was 14.0 months. The main causes of death were disease progression (30.8%) and TRT (27.1%). In multivariate analysis, overall survival was affected by aaIPI, hypoalbuminemia, elevated creatinine, and treatment. Conclusion Age itself should not be a contraindication to treatment. However, since elderly patients show higher rates of TRT due to infection, careful monitoring and dose modification of chemotherapeutic agents is needed.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Coiffier B / 2002 / CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma / N Engl J Med 346:235~242
Feugier P / 2005 / Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d'Etude des Lymphomes de l'Adulte / J Clin Oncol 23:4117~4126
Peyrade F / 2011 / Attenuated immunochemotherapy regimen (R-miniCHOP) in elderly patients older than 80 years with diffuse large B-cell lymphoma: a multicentre, single-arm, phase 2 trial / Lancet Oncol 12:460~468
정윤화 / 2015 / Clinical characteristics and outcomes in diffuse large B cell lymphoma patients aged 70 years and older: a single-center experience with a literature review / The Korean Journal of Internal Medicine 30(5):684~693
하혜림 / 2016 / Reduced Dose Intensities of Doxorubicin in Elderly Patients with DLBCL in Rituximab Era / Cancer Research and Treatment 48(1):304~311
Feugier P / 2005 / Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d'Etude des Lymphomes de l'Adulte / J Clin Oncol 23:4117~4126
Peyrade F / 2011 / Attenuated immunochemotherapy regimen (R-miniCHOP) in elderly patients older than 80 years with diffuse large B-cell lymphoma: a multicentre, single-arm, phase 2 trial / Lancet Oncol 12:460~468
정윤화 / 2015 / Clinical characteristics and outcomes in diffuse large B cell lymphoma patients aged 70 years and older: a single-center experience with a literature review / The Korean Journal of Internal Medicine 30(5):684~693
하혜림 / 2016 / Reduced Dose Intensities of Doxorubicin in Elderly Patients with DLBCL in Rituximab Era / Cancer Research and Treatment 48(1):304~311
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Navigating the Gray Zone: Physicians’ Perspectives on Treatment Decision-Making in Elderly Cancer Patients in Korea
임상노인의학회지
2024 .08
-
Surgical Treatment for Elderly Patients with Pancreatic Cancer
대한외과학회 학술대회 초록집
2022 .11
-
Early-Stage Breast Cancer in the Elderly: Confronting an Old Clinical Problem
Journal of Breast Cancer
2015 .01
-
Clinicopathologic Features and Long-Term Outcomes of Elderly Breast Cancer Patients: Experiences at a Single Institution in Korea
Cancer Research and Treatment
2016 .01
-
The novel use and feasibility of hemostatic oxidizied regenerated cellulose agent (Surgeiuard®) : Multicenter retrospective study
대한외과학회 학술대회 초록집
2019 .10
-
Surgical management for elderly patients with pancreatic cancer
Annals of Surgical Treatment and Research
2023 .08
-
Clinical features and treatment outcomes of Hodgkin lymphoma: A retrospective review in a Malaysian tertiary hospital
Blood Research
2019 .01
-
Treatment of indolent lymphoma
Blood Research
2022 .04
-
상담자 요소가 이명재훈련치료의 효과에 미치는 영향
대한이비인후-두경부외과학회지
2017 .01
-
Efficacy and Safety of Surgical Resection in Elderly Patients with Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Gut and Liver
2024 .07
-
Active Treatment Improves Overall Survival in Extremely Older Non-Small Cell Lung Cancer Patients: A Multicenter Retrospective Cohort Study
Cancer Research and Treatment
2021 .01
-
Diffuse large B-cell lymphoma presenting with cholecystitis-like symptoms
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2018 .06
-
고령의 두경부암 환자의 적절한 수술
임상이비인후과
2017 .12
-
이명 환자를 대상으로 한 모바일 기기 기반의 이명재훈련치료의 효용성
대한이비인후-두경부외과학회지
2023 .05
-
Clinical characteristics and treatment outcomes of children and adolescents with aggressive mature B-cell lymphoma: a single-center analysis
Blood Research
2022 .03
-
Analysis of the Clinicopathological Characteristics of Gastric Cancer in Extremely Old Patients
Cancer Research and Treatment
2017 .01
-
Outcome of Colorectal Surgery in Elderly Populations
Annals of Coloproctology
2016 .01
-
Diffuse large B cell lymphoma with high M protein: an unusual finding
Blood Research
2015 .01
-
Relapse of Ocular Lymphoma following Primary Testicular Diffuse Large B-cell Lymphoma
Journal of Retina
2023 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0