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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 132 - 139 (8page)
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초록· 키워드
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Purpose: This study was conducted to explore whether CDCA derivatives induce apoptosis in a stomach cancer cell line, and to dissect the detailed mechanism underlying apoptosis. Materials and Methods: The human stomach cancer cell line, SNU-1, cells were treated with the synthetic CDCA derivatives, HS-1199 and HS-1200. DNA and mitochondrial stains were used to detect apoptotic cells by fluorescence imaging or flow cytometry. The caspase-3 activity was measured by Western blotting. Results: Both the HS-1199 and HS-1200 induced decreased viabilities of the SNU-1 cells, in time-dependent manners. The CDCA derivatives demonstrated various apoptosis hallmarks, such as mitochondrial changes (reduction of MMP, cytochrome c release, and Smac/ DIABLO translocation), activation of caspase-3 (resulting in the degradation of PARP and DFF45), DNA fragmentation and nuclear condensation. Conclusion: The CDCA derivatives, HS-1199 and HS- 1200, both induced apoptosis of the SNU-1 gastric cancer cells in caspase- and mitochondria-dependent fashions. Many important issues relating to their therapeutic applications remain to be elucidated. (Cancer Res Treat. 2004;36:132-139)
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참고문헌 (26)
참고문헌 신청
/ 1994 / Cleavage of poly(ADP-ribose)polymerase by aproteinase with properties like ICE 371 : 346 ~ 347
/ 1995 / Degradation of lamin B1 precedes oligonucleosomal DNA fragmentationin apoptotic thymocytes and isolated thymocytenuclei 154 : 3788 ~ 3795
/ 1996 / Bile acid stimulation ofearly growth response gene and mitogen-activated proteinkinase is protein kinase C-dependent 316 : 756 ~ 769
/ 1997 / Biochemical characterizationof the protein activity responsible for high molecular weightDNA fragmentation during drug-induced apoptosis 57 : 3407 ~ 3414
/ 1997 / Expression andregulation of Bcl-2,Bcl-xl,and Bax correlate with p53 statusand sensitivity to apoptosis in childhood acute lymphoblasticleukemia 89 : 2986 ~ 2993
/ 1995 / Degradation of lamin B1 precedes oligonucleosomal DNA fragmentationin apoptotic thymocytes and isolated thymocytenuclei 154 : 3788 ~ 3795
/ 1996 / Bile acid stimulation ofearly growth response gene and mitogen-activated proteinkinase is protein kinase C-dependent 316 : 756 ~ 769
/ 1997 / Biochemical characterizationof the protein activity responsible for high molecular weightDNA fragmentation during drug-induced apoptosis 57 : 3407 ~ 3414
/ 1997 / Expression andregulation of Bcl-2,Bcl-xl,and Bax correlate with p53 statusand sensitivity to apoptosis in childhood acute lymphoblasticleukemia 89 : 2986 ~ 2993
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