지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 121 - 126 (6page)
이용수
초록· 키워드
오류제보하기
Purpose Apolipoprotein E (APOE, MIM: 107741) has three functionally distinct isoforms of the protein (E2,E3, and E4), encoded by corresponding alleles ε2, ε3, and ε4, which have been well described.
Findings from previous studies investigating association between APOE polymorphisms and breast cancer risk have been inconsistent. The present meta-analysis was conducted in order to investigate association of APOE polymorphisms with risk of breast cancer.
Materials and Methods Several electronic databases were used for identification of studies containing information on APOE polymorphisms and breast cancer risk published up to January 2012. We identified 10eligible studies, including 3,835 subjects (2008 patients, and 1,827 healthy controls), that reported on polymorphisms of APOE and risk of breast cancer. Summary odds ratios (ORs) and 95%confidence intervals (CIs) were obtained using a fixed and random-effects models.
Results Among studies reported from Asia, an association of the ε4 allele with increased risk of breast cancer, in comparison with the ε3 allele, was observed (OR, 1.56; 95% CI, 1.19 to 2.04; p=0.001). It should be noted that allele ε2 showed no association with breast cancer risk. Among Caucasians,neither the ε4 (OR, 0.99; 95% CI, 0.83 to 1.17; p=0.917) nor the ε2 (OR, 0.92; 95% CI, 0.72 to 1.17;p=0.514) allele showed an association with susceptibility to breast cancer, when compared with the ε3 allele. Carriers of the ε4 allele (E4E4, E4E3, and E4E2 genotypes), in comparison with the E3E3 genotype, showed an association with elevated risk of breast cancer only among Asians (OR, 1.75; 95% CI, 1.23 to 2.47; p=0.002). No publication bias was detected.
Conclusion This meta-analysis suggest that the APOEε4 allele is a low-penetrant risk factor for development of breast cancer.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Agurs-Collins T / 1998 / Plasma lipid alterations in African-American women with breast cancer / J Cancer Res Clin Oncol 124 : 186 ~ 190
Bennet AM / 2007 / Association of apolipoprotein E genotypes with lipid levels and coronary risk / JAMA 298 : 1300 ~ 1311
Carroll KK / 1986 / Fat and cancer / Cancer 58 (8 Suppl) : 1818 ~ 1825
Chang NW / 2005 / Influences of apolipoprotein E polymorphism on the risk for breast cancer and HER2/neu status in Taiwan / Breast Cancer Res Treat 90 : 257 ~ 261
Chang SJ / 2006 / Association between the apolipoprotein E genotypes and breast cancer patients in Taiwanese / Breast Cancer Res Treat 98 : 109 ~ 113
Bennet AM / 2007 / Association of apolipoprotein E genotypes with lipid levels and coronary risk / JAMA 298 : 1300 ~ 1311
Carroll KK / 1986 / Fat and cancer / Cancer 58 (8 Suppl) : 1818 ~ 1825
Chang NW / 2005 / Influences of apolipoprotein E polymorphism on the risk for breast cancer and HER2/neu status in Taiwan / Breast Cancer Res Treat 90 : 257 ~ 261
Chang SJ / 2006 / Association between the apolipoprotein E genotypes and breast cancer patients in Taiwanese / Breast Cancer Res Treat 98 : 109 ~ 113
이 논문의 저자 정보
최근 본 자료
댓글(0)
0