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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 120 - 125 (6page)
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초록· 키워드
오류제보하기
Intramucosal gastric cancer (IGC) is associated with a very low risk of lymph nodemetastasis; thus it is the main candidate for minimally invasive surgical procedures,such as endoscopic submucosal dissection (ESD). Herein, we document an extraordinarycase of IGC, which showed a very aggressive clinical course. A 66-year-old femaleunderwent ESD for early gastric cancer. Histologically, the tumor consistedmainly of moderately differentiated adenocarcinoma measuring 1.6 cm in diameter,and the tumor was confined to the mucosa. Despite annual esophagogastroduodenoscopicfollow-up, the tumor recurred, with wide metastasis to multiple lymph nodesand bones throughout the body after three years. Fluorescence in situ hybridizationstudy demonstrated MET gene amplification as well as low grade polysomy 7 in bothoriginal and recurrent tumors. The clinical characteristics of metastatic IGCs and theimplication of MET amplification are discussed.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Angeles-Angeles A / 1998 / A clinicopathologic variant of intramucosal early gastric cancer with widespread dissemination : report of three cases / J Clin Gastroenterol 27 :
Bang YJ / 2010 / Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer(
Corso S / 2005 / Cancer therapy: can the challenge be MET? / Trends Mol Med 11 : 284 ~ 292
Graziano F / 2011 / Genetic activation of the MET pathway and prognosis of patients with high-risk, radically resected gastric cancer / J Clin Oncol 29 : 4789 ~ 4795
Hanaoka N / 2009 / A rare case of histologically mixed-type intramucosal gastric cancer accompanied by nodal recurrence and liver metastasis after endoscopic submucosal disse
Bang YJ / 2010 / Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer(
Corso S / 2005 / Cancer therapy: can the challenge be MET? / Trends Mol Med 11 : 284 ~ 292
Graziano F / 2011 / Genetic activation of the MET pathway and prognosis of patients with high-risk, radically resected gastric cancer / J Clin Oncol 29 : 4789 ~ 4795
Hanaoka N / 2009 / A rare case of histologically mixed-type intramucosal gastric cancer accompanied by nodal recurrence and liver metastasis after endoscopic submucosal disse
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