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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,140 - 1,148 (9page)
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초록· 키워드
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Purpose This study aimed to identify predictors for distant metastatic behavior and build a related prognostic nomogram in breast cancer. Materials and Methods A total of 1,181 patients with non-metastatic breast cancer between 2003 and 2011 were analyzed. To predict the probability of distant metastasis, a nomogram was constructed based on prognostic factors identified using a Cox proportional hazards model. Results The 7-year overall survival and 5-year post-progression survival of locoregional versus distant recurrence groups were 67.6% versus 39.1% (p=0.027) and 54.2% versus 33.5% (p=0.043), respectively. Patients who developed distant metastasis showed early and late mortality risk peaks within 3 and after 5 years of follow-up, respectively, but a broad and low risk increment was observed in other patients with locoregional relapse. In multivariate analysis of distant metastasis-free interval, age ( 45 years vs. < 45 years), molecular subtypes (luminal A vs. luminal B, human epidermal growth receptor 2, and triple negative), T category (T1 vs. T2-3 and T4), and N category (N0 vs. N1 and N2-3) were independently associated (p < 0.05 for all). Regarding the significant factors, a well-validated nomogram was established (concordance index, 0.812). The risk score level of patients with initial brain failure was higher than those of non-brain sites (p=0.029). Conclusion The nomogram could be useful for predicting the individual probability of distant recurrence in breast cancer. In high-risk patients based on the risk scores, more aggressive systemic therapy and closer surveillance for metastatic failure should be considered.
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참고문헌 (29)
참고문헌 신청
Siegel RL / 2016 / Cancer statistics, 2016 / CA Cancer J Clin 66:7~30
National Comprehensive Cancer Network / 2017 / Breast cancer version 2.2017 [Internet]
National Institute for Health and Care Excellence / Adjuvant therapy for early and locally advanced breast cancer
Wu SG / 2017 / The effect of distant metastases sites on survival in de novo stage- IV breast cancer: a SEER database analysis / Tumour Biol 39
Wu Q / 2017 / Breast cancer subtypes predict the preferential site of distant metastases: a SEER based study / Oncotarget 8:27990~27996
National Comprehensive Cancer Network / 2017 / Breast cancer version 2.2017 [Internet]
National Institute for Health and Care Excellence / Adjuvant therapy for early and locally advanced breast cancer
Wu SG / 2017 / The effect of distant metastases sites on survival in de novo stage- IV breast cancer: a SEER database analysis / Tumour Biol 39
Wu Q / 2017 / Breast cancer subtypes predict the preferential site of distant metastases: a SEER based study / Oncotarget 8:27990~27996
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