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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,362 - 1,377 (16page)
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Purpose Tumor xenograft model is an indispensable animal cancer model. In esophageal squamous cell carcinoma (ESCC) research, orthotopic tumor xenograft model establishes tumor xenograft in the animal esophagus, which allows the study of tumorigenesis in its native microenvironment. Materials and Methods In this study, we described two simple and reproducible methods to develop tumor xenograft at the cervical or the abdominal esophagus in nude mice by direct injection of ESCC cells in the esophageal wall. Results In comparing these two methods, the cervical one presented with more clinically relevant features, i.e., esophageal stricture, body weight loss and poor survival. In addition, the derived tumor xenografts accompanied a rapid growth rate and a high tendency to invade into the surrounding structures. This model was subsequently used to study the anti-tumor effect of curcumin, which is known for its potential therapeutic effects in various diseases including cancers, and its analogue SSC-5. SSC-5 was selected among the eight newly synthesized curcumin analogues based on its superior anti-tumor effect demonstrated in an MTT cell proliferation assay and its effects on apoptosis induction and cell cycle arrest in cultured ESCC cells. Treatment of orthotopic tumor-bearing mice with SSC-5 resulted in an inhibition in tumor growth and invasion. Conclusion Taken together, we have established a clinically relevant orthotopic tumor xenograft model that can serve as a preclinical tool for screening new anti-tumor compounds, e.g., SSC-5, in ESCC.
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참고문헌 (34)
참고문헌 신청
Killion JJ / 1998 / Orthotopic models are necessary to predict therapy of transplantable tumors in mice / Cancer Metastasis Rev 17:279~284
Fidler IJ / 1994 / Modulation of tumor cell response to chemotherapy by the organ environment / Cancer Metastasis Rev 13:209~222
Dong Z / 1994 / Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells / J Natl Cancer Inst 86:913~920
Hori T / 2001 / A novel orthotopic implantation model of human esophageal carcinoma in nude rats: CD44H mediates cancer cell invasion in vitro and in vivo / Int J Cancer 92:489~496
Ohara T / 2010 / The establishment of a new mouse model with orthotopic esophageal cancer showing the esophageal stricture / Cancer Lett 293:207~212
Fidler IJ / 1994 / Modulation of tumor cell response to chemotherapy by the organ environment / Cancer Metastasis Rev 13:209~222
Dong Z / 1994 / Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells / J Natl Cancer Inst 86:913~920
Hori T / 2001 / A novel orthotopic implantation model of human esophageal carcinoma in nude rats: CD44H mediates cancer cell invasion in vitro and in vivo / Int J Cancer 92:489~496
Ohara T / 2010 / The establishment of a new mouse model with orthotopic esophageal cancer showing the esophageal stricture / Cancer Lett 293:207~212
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