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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제15권 제5호
- 발행연도
- 2011.1
- 수록면
- 259 - 266 (8page)
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초록· 키워드
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The aim of this study was to evaluate the preventive role of epigallocatechin-3 gallate (EGCG, a derivative of green tea) in ischemia/reperfusion (I/R) injury of isolated rat hearts. It has been suggested that EGCG has beneficial health effects, including prevention of cancer and heart disease, and it is also a potent antioxidant. Rat hearts were subjected to 20 min of normoxia, 20 min of zero-flow ischemia and then 50 min of reperfusion. EGCG was perfused 10 min before ischemia and during the whole reperfusion period. EGCG significantly increased left ventricular developed pressure (LVDP) and increased maximum positive and negative dP/dt (＋/-dP/dtmax). EGCG also significantly increased the coronary flow (CF) at baseline before ischemia and at the onset of the reperfusion period. Moreover, EGCG decreased left ventricular end diastolic pressure (LVEDP). This study showed that lipid peroxydation was inhibited and Mn-SOD and catalase expressions were increased in the presence of EGCG. In addition, EGCG increased levels of Bcl-2, Mn-superoxide dismutase (SOD), and catalase expression and decreased levels of Bax and increased the ratio of Bcl-2/Bax in isolated rat hearts. Cleaved caspase-3 was decreased after EGCG treatment. EGCG markedly decreased the infarct size while attenuating the increase in lactate dehydrogenase (LDH) levels in the effluent. In summary, we suggest that EGCG has a protective effect on I/R-associated hemodynamic alteration and injury by acting as an antioxidant and anti-apoptotic agent in one.
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참고문헌 (25)
참고문헌 신청
Buja LM / 2005 / Myocardial ischemia and reperfusion injury / Cardiovasc Pathol 14 : 170 ~ 175
Devika PT / 2008 / (-)E
Hirai M / 2007 / Protective effects of EGCg or GCg, a green tea catechin epimer, against postischemic myocardial dysfunction in guinea-pig hearts / Life Sci 80 : 1020 ~ 1032
Katiyar S / 2007 / Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair / J Nutr Biochem 18 : 287 ~ 296
Kris-Etherton PM / 2002 / Evidence that the antioxidant flavonoids in tea and cocoa are beneficial for cardiovascular health / Curr Opin Lipidol 13 : 41 ~ 49
Devika PT / 2008 / (-)E
Hirai M / 2007 / Protective effects of EGCg or GCg, a green tea catechin epimer, against postischemic myocardial dysfunction in guinea-pig hearts / Life Sci 80 : 1020 ~ 1032
Katiyar S / 2007 / Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair / J Nutr Biochem 18 : 287 ~ 296
Kris-Etherton PM / 2002 / Evidence that the antioxidant flavonoids in tea and cocoa are beneficial for cardiovascular health / Curr Opin Lipidol 13 : 41 ~ 49
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