농촌지역 고혈압 전단계 성인의 혈청 Gamma-Glutamyltransferase와 고혈압 발생률간의 관련성

황준현; 신지연; 이덕희; 김건엽; 박의현; 채성철; 천병렬

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자료유형: 학술저널

저자정보: 황준현 신지연 이덕희 김건엽 박의현 채성철 천병렬

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제43권 제1호

발행연도: 2010.1

수록면: 18 - 25 (8page)

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Objectives: Prehypertension is associated with a higher risk of developing hypertension compared with normotension. Yet,factors predicting the development of hypertension among prehypertensive people are ill-understood. This prospective cohort study was performed to examine if serum gamma-glutamyltrasferase (GGT) within a normal range can predict the future risk of hypertension among prehypertensive adults. Methods: Study subjects were 293 prehypertensive persons >30-years-of-age who participated in a community-based health survey in 2003 and who were followed up in 2008. Sex-specific quartiles of baseline serum GGT were used to examine association with 5-year hypertension incidence. Results: Baseline serum GGT within normal range predicted the risk of developing hypertension for 5 years only in prehypertensive women. Adjusted relative risks were 1.0, 3.7, 3.6, and 6.0 according to quartiles of baseline serum GGT (P for trend <0.01). This pattern was similarly observed in non-drinkers. However, serum GGT was not associated with incident hypertension in men. Different from serum GGT, baseline serum alanine aminotransferase, another well-known liver enzyme,did not predict the risk of incident hypertension in both genders. Conclusions: Even though baseline serum GGT within normal range strongly predicted the future risk of hypertension, it was observed only in women, Although underlying mechanisms of this association are currently unclear, serum GGT can be used to select a high risk group of hypertension in prehypertensive women.

#Gamma-glutamyltransferase #Hypertension #Incidence #Prehypertension

참고문헌 (21)

참고문헌 신청

Chobanian AV / 2003 / Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure / Hypertension 42 (6) : 1206 ~

Chobanian AV / 2003 / The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 report / JAMA 2

Ikai E / 1993 / Serum gamma-glutamyl transpeptidase levels and hypertension in non-drinkers: A possible role of fatty liver in the pathogenesis of obesity related hypertensi

Ikai E / 1994 / Serum gamma-glutamyl transpeptidase level and blood pressure in nondrinkers: A possible pathogenetic role of fatty liver in obesity-related hypertension / J

Kawamoto R. / 2008 / Association between serum gamma-glutamyl transferase level and prehypertension among communitydwelling men / Tohoku J Exp Med 216 (3) : 213 ~ 221

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