지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 157 - 165 (9page)
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Purpose As a result of various independently proposed nomenclatures and classifications, there is confusion in the diagnosis and prediction of biological behavior of gastroenteropancreatic neuroendocrine tumors (GEP-NETs). A comprehensive nationwide study is needed in order to understand the biological characteristics of GEP-NETs in Korea.
Materials and Methods We collected 4,951 pathology reports from 29 hospitals in Korea between 2000 and 2009. Kaplan-Meier survival analysis was used to determine the prognostic significance of clinicopathological parameters.
Results Although the GEP-NET is a relatively rare tumor in Korea, its incidence has increased during the last decade, with the most significant increase found in the rectum. The 10-year survival rate for well-differentiated endocrine tumor was 92.89%, in contrast to 85.74% in well differentiated neuroendocrine carcinoma and 34.59% in poorly differentiated neuroendocrine carcinoma.
Disease related death was most common in the biliary tract (62.2%) and very rare in the rectum (5.2%). In Kaplan-Meier survival analysis, tumor location, histological classification, extent, size,mitosis, Ki-67 labeling index, synaptophysin expression, lymphovascular invasion, perineural invasion, and lymph node metastasis showed prognostic significance (p＜0.05), however, chromogranin expression did not (p=0.148). The 2000 and 2010 World Health Organization (WHO)classification proposals were useful for prediction of the prognosis of GEP-NET.
Conclusion The incidence of GEP-NET in Korea has shown a remarkable increase during the last decade,however, the distribution of tumors in the digestive system differs from that of western reports.
Assessment of pathological parameters, including immunostaining, is crucial in understanding biological behavior of the tumor as well as predicting prognosis of patients with GEP-NET.
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참고문헌 (24)
참고문헌 신청
[학술지(정기
Arnold R. / 2005 / Introduction : definition, historical aspects, classification, staging, prognosis and therapeutic options / Best Pract Res Clin Gastroenterol 19 : 491 ~ 5
Bosman FT / 2010 / WHO classification of tumours of the digestive system. 4th ed / International Agency for Research on Cancer
Boudreaux JP / 2010 / The NANETS consensus guideline for the diagnosis and management of neuroendocrine tumors : well-differentiated neuroendocrine tumors of the jejunum, ile
Chetty R. / 2008 / An overview of practical issues in the diagnosis of gastroenteropancreatic neuroendocrine pathology / Arch Pathol Lab Med 132 : 1285 ~ 1289
Arnold R. / 2005 / Introduction : definition, historical aspects, classification, staging, prognosis and therapeutic options / Best Pract Res Clin Gastroenterol 19 : 491 ~ 5
Bosman FT / 2010 / WHO classification of tumours of the digestive system. 4th ed / International Agency for Research on Cancer
Boudreaux JP / 2010 / The NANETS consensus guideline for the diagnosis and management of neuroendocrine tumors : well-differentiated neuroendocrine tumors of the jejunum, ile
Chetty R. / 2008 / An overview of practical issues in the diagnosis of gastroenteropancreatic neuroendocrine pathology / Arch Pathol Lab Med 132 : 1285 ~ 1289
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