지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Finite element analysis(FEA) has been extensively applied in the analyses of biomechanical properties of stents. Geometrically, a closed-cell stent is an assembly of a number of repeated unit cells and exhibits periodicity in both longitudinal and circumferential directions. This study concentrates on various parameters of the FEA models for the analysis of drug-eluting biodegradable polymeric stents for application to the treatment of coronary artery disease. In order to determine the mechanical characteristics of biodegradable polymeric stents, FEA was used to model two different types of stents: tubular stents(TS) and helicoidal stents(HS). For this modeling, epigallocatechin-3-O-gallate (EGCG)-eluting poly[(L-lactide-co-ε-caprolactone), PLCL] (E-PLCL) was chosen as drug-eluting stent materials. E-PLCL was prepared by blending PLCL with 5% EGCG as previously described. In addition, the effects of EGCG blending on the mechanical properties of PLCL were investigated for both types of stent models. EGCG did not affect tensile strength at break, but significantly increased elastic modulus of PLCL. It is suggested that FEA is a cost-effective method to improve the design of drug-eluting biodegradable polymeric stents.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
A. Alcocer. / 2006 / Clinical variables related with in-stent restenosis late regression after bare metal coronary stenting / Arch Cardiol Mex. 76 (4) : 390 ~ 396
C. Dumoulin / 2000 / Mechanical behaviour modelling of balloon-expandable stents / J Biomech. 33 (11) : 1461 ~ 1470
C. Lally / 2005 / Cardiovascular stent design and vessel stresses : a finite element analysis / J Biomech. 38 (8) : 1574 ~ 1581
D. Martin / 2011 / Computational structural modelling of coronary stent deployment : a review / Comput Methods Biomech Biomed Engin. 14 (4) : 331 ~ 348
D.S. Baim / 1997 / Stent thrombosis. Closing in on the best preventive treatment / Circulation 95 (5) : 1098 ~ 1100
C. Dumoulin / 2000 / Mechanical behaviour modelling of balloon-expandable stents / J Biomech. 33 (11) : 1461 ~ 1470
C. Lally / 2005 / Cardiovascular stent design and vessel stresses : a finite element analysis / J Biomech. 38 (8) : 1574 ~ 1581
D. Martin / 2011 / Computational structural modelling of coronary stent deployment : a review / Comput Methods Biomech Biomed Engin. 14 (4) : 331 ~ 348
D.S. Baim / 1997 / Stent thrombosis. Closing in on the best preventive treatment / Circulation 95 (5) : 1098 ~ 1100
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