지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이 논문의 연구 히스토리 (9)
2012
2010
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초록· 키워드
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The purpose of this study is to investigate whether medication and deep brain stimulation (DBS) have differential effects on the speed and amplitude of bradykinesia in patients with Parkinson's disease (PD). Five PD patients with implanted DBS electrodes (age: 60.6 ± 7.4 yrs, H&Y stage: 3.1 ± 0.2) participated in this study. FT (finger tapping) movement was measured using a gyrosensor system in four treatment conditions: Med (Medication)-off/DBS-off, Med-off/DBS-on, Med-on/DBS-off and Med-on/DBS-on. Quantitative measures representing average speed and amplitude of FT movement included root-mean-squared (RMS) angular velocity and RMS angle. One-way repeated measures ANOVA showed that RMS angular velocity of Med-on/DBS-on was significantly greater than those of Med-off/DBS-off and Med-off/DBS-on (p < 0.01) whereas RMS angle was not different among conditions (p = 0.06). Two way repeated measures ANOVA showed that only medication improved RMS angular velocity (p < 0.01), whereas both medication and DBS had no significant effect on RMS angle (p > 0.02). Effect size of RMS angular velocity was greater than that of RMS angle in both medication and DBS. This suggests that medication and DBS have differential effects on FT bradykinesia and velocity and amplitude impairments may be associated with different functional aspects in PD.
목차
등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
A. Kandori / 2004 / Quantitative magnetic detection of finger movements in patients with Parkinson's disease / Neurosci Res 49 (2) : 253 ~ 260
A.J. Espay / / Differential response of speed, amplitude, and rhythm to dopaminergic medications in Parkinson's disease / Mov Disord 26 (14) : 2504 ~ 2508
A.J. Espay / 2009 / Impairments of speed and amplitude of movement in Parkinson's disease: a pilot study / Mov Disord 24 (7) : 1001 ~ 1008
C.G. Goetz / 2008 / Movement Disorder Society- sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing resu
J.W. Kim / 2011 / Quantification of bradykinesia during clinical finger taps using a gyrosensor in patients with Parkinson's disease / Med. Biol. Eng. Comput. 49 (3) : 365 ~
A.J. Espay / / Differential response of speed, amplitude, and rhythm to dopaminergic medications in Parkinson's disease / Mov Disord 26 (14) : 2504 ~ 2508
A.J. Espay / 2009 / Impairments of speed and amplitude of movement in Parkinson's disease: a pilot study / Mov Disord 24 (7) : 1001 ~ 1008
C.G. Goetz / 2008 / Movement Disorder Society- sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing resu
J.W. Kim / 2011 / Quantification of bradykinesia during clinical finger taps using a gyrosensor in patients with Parkinson's disease / Med. Biol. Eng. Comput. 49 (3) : 365 ~
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