지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Dielectrophoresis(DEP) is useful in manipulation and separation of micro-sized particles including biological samples such as bacteria, blood cells, and cancer cells in a micro-fluidic device. Especially, those separation and manipulation techniques using DEP in combination of micro fabrication technique have been researched more and more. Recently, it is revealed that a window structure of insulating layer in microfluidic DEP chip is key role in trap of micro-particles around the window structure. However, the trap phenomenon-driven by DEP force gradient did not fully understand and is still illusive. In this study, we characterize the trap mechanism and efficiency with different shapes of window in a microfluidic DEP chip. To do this characterization, we fabricated 4 different windows shapes such as rhombus, circle, squares, and hexagon inside a micro-fluidic chip, and performed micro-sized particles manipulation experiments as varying the frequency and voltage of AC signal. Moreover, the numerical simulation with the same parameters that were used in the experiment was also performed in order to compare the simulation results and the experimental results. Those comparison shows that both results are closely matched. This study may be helpful in design and development of microfluidic DEP chip for trapping micro-scaled biological particle.
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참고문헌 (15)
참고문헌 신청
Chen, J. / 2011 / Electrodeformation for single cell mechanical characterization / JOURNAL OF MICROMECHANICS AND MICROENGINEERING 21 (5) : 054012 ~
D'souza, S. F. / 2001 / Microbial biosensors / Biosensors and Bioelectronics 16 : 337 ~ 353
Huang, Y. / 1997 / Introducing dielectrophoresis as a new force field for field-flow fractionation / Biophysical journal 73 (2) : 1118 ~ 1129
Manaresi, N. / 2003 / A CMOS chip for individual cell manipulation and detection / Solid-State Circuits, IEEE Journal of vol 38 (12) : 2297 ~ 2305
Markx, G. H. / 1997 / DEP-FFF : Field-flow fractionation using non-uniform electric fields / Journal of liquid chromatography & related technologies 20 (16-17) : 2857 ~
D'souza, S. F. / 2001 / Microbial biosensors / Biosensors and Bioelectronics 16 : 337 ~ 353
Huang, Y. / 1997 / Introducing dielectrophoresis as a new force field for field-flow fractionation / Biophysical journal 73 (2) : 1118 ~ 1129
Manaresi, N. / 2003 / A CMOS chip for individual cell manipulation and detection / Solid-State Circuits, IEEE Journal of vol 38 (12) : 2297 ~ 2305
Markx, G. H. / 1997 / DEP-FFF : Field-flow fractionation using non-uniform electric fields / Journal of liquid chromatography & related technologies 20 (16-17) : 2857 ~
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