지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Although recent studies have shown the usibility of [F-18]FDG small animal Positron Emission Tommography (PET) as a functional neuroimaging technique in behavioural small animal study, researches showing the detection power of functional changes in the brain are still limited. Thus, in the study, we performed [F-18]FDG small animal PET neuroimaging in the well-established fear behavioural experiment. Twelve rats were exposed on cat for 30 minutes after the [F-18]FDG injection. As a result, the brain activity in bilateral amygdala areas significantly increased in the fear condition. In addition, the fear condition evoked the functional activities of hypothalamus, which seemed to be related to the response to stress. These clear localization of fear related brain regions may reflect that a functional neuroimaging technique using [F-18]FDG small animal PET has functional detectibility enough to be applied in small animal behavioral research.
목차
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참고문헌 (16)
참고문헌 신청
A. Valles / 2006 / Long-term effects of a single exposure to immobilization: a c-fos mRNA study of the response to the homotypic stressor in the rat brain / J. neurobiol 66
A. Van der Linden / 2007 / Current status of functional MRI on small animals: application to physiology, pathophysiology, and cognition / NMR Biomed 20 : 522 ~ 545
B. J. Fueger / 2006 / Impact of animal handling on the results of 18f-FDG Pet studies in mice / J. Nucl. Med 47 : 999 ~ 1006
D. P. Jang / 2009 / Effects of fluoxetine on the rat brain in the forced swimming test: a [F-18]FDG micro-PET imaging study / Neurosci Lett 451 : 60 ~ 64
D. P. Jang / 2009 / Neural responses of rats in the forced swimming test: [F-18]FDG micro PET study / Behav Brain Res 203 : 43 ~ 47
A. Van der Linden / 2007 / Current status of functional MRI on small animals: application to physiology, pathophysiology, and cognition / NMR Biomed 20 : 522 ~ 545
B. J. Fueger / 2006 / Impact of animal handling on the results of 18f-FDG Pet studies in mice / J. Nucl. Med 47 : 999 ~ 1006
D. P. Jang / 2009 / Effects of fluoxetine on the rat brain in the forced swimming test: a [F-18]FDG micro-PET imaging study / Neurosci Lett 451 : 60 ~ 64
D. P. Jang / 2009 / Neural responses of rats in the forced swimming test: [F-18]FDG micro PET study / Behav Brain Res 203 : 43 ~ 47
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