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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 246 - 249 (4page)
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Emerging resistance to trimethoprim/sulfamethoxazole (SXT) poses a serious threat to the treatment of Stenotrophomonas maltophilia infections. We determined the prevalence and molecular characteristics of acquired SXT resistance in recent clinical S. maltophilia isolates obtained from Korea. A total of 252 clinical isolates of S. maltophilia were collected from 10 university hospitals in Korea between 2009 and 2010. Antimicrobial susceptibility was determined by using the CLSI agar dilution method. The sul1, sul2, and sul3 genes, integrons, insertion sequence common region (ISCR) elements, and dfrA genes were detected using PCR. The presence of the sul1 gene and integrons was confirmed through sequence analysis. Among the 32 SXT-resistant isolates, sul1 was detected in 23 isolates (72%), all of which demonstrated high-level resistance (≥64 mg/L) to SXT. The sul1 gene (varying in size and structure) was linked to class 1 integrons in 15 of the 23 isolates (65%) harboring this gene. None of the SXT-susceptible isolates or the SXT-resistant isolates with a minimum inhibitory concentration of 4 and 8 mg/L were positive for sul1. Moreover, the sul2, sul3, and dfrA genes or the ISCR elements were not detected. The sul1 gene may play an important role in the high-level SXT resistance observed in S. maltophilia.
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참고문헌 (16)
참고문헌 신청
Al-Jasser AM / 2006 / Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole: an increasing problem / Ann Clin Microbiol Antimicrob 5 : 23 ~
Bae IK / 2007 / Novel complex class 1 integron bearing an ISCR1 element in an Escherichia coli isolate carrying the blaCTX-M-14 gene / Antimicrob Agents Chemother 51 : 3017
Baquero F / 2001 / Low-level antibacterial resistance: a gateway to clinical resistance / Drug Resist Updat 4 : 93 ~ 105
Barbolla R / 2004 / Class 1 integrons increase trimethoprim-sulfamethoxazole MICs against epidemiologically unrelated Stenotrophomonas maltophilia isolates / Antimicrob Agent
Brooke JS / 2012 / Stenotrophomonas maltophilia: an emerging global opportunistic pathogen / Clin Microbiol Rev 25 : 2 ~ 41
Bae IK / 2007 / Novel complex class 1 integron bearing an ISCR1 element in an Escherichia coli isolate carrying the blaCTX-M-14 gene / Antimicrob Agents Chemother 51 : 3017
Baquero F / 2001 / Low-level antibacterial resistance: a gateway to clinical resistance / Drug Resist Updat 4 : 93 ~ 105
Barbolla R / 2004 / Class 1 integrons increase trimethoprim-sulfamethoxazole MICs against epidemiologically unrelated Stenotrophomonas maltophilia isolates / Antimicrob Agent
Brooke JS / 2012 / Stenotrophomonas maltophilia: an emerging global opportunistic pathogen / Clin Microbiol Rev 25 : 2 ~ 41
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