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학술저널
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대한진단검사의학회 Laboratory Medicine Online Laboratory Medicine Online 제1권 제1호
발행연도
2011.1
수록면
51 - 56 (6page)

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Background: For the diagnosis of tuberculosis (TB), a variety of tests based on the patients’ immune response has been introduced. We evaluated the clinical usefulness of combined anti-tuberculosis antibody (anti-TB Ab) test and Interferon-γ release assay (IGRA), evaluating humoral and cellular immune response to Mycobacterium tuberculosis, respectively. Methods: Among patients tested for IGRA, 78 patients diagnosed as TB and treated with anti-TB drug and 80 non-TB patients were included in this study. We used QuantiFERON-TB GOLD (QFT, Cellestis limited, Australia) for IGRA and an immunochromatographic assay, Easy Test TB (ASAN PHARM, Korea), for anti-TB Ab test. Results: The sensitivity, specificity, and positive and negative predictive values of Easy Test TB were 23.1%, 98.8%, 94.7% and 56.8%, respectively. QFT had a significantly higher sensitivity than Easy Test TB (67.9% vs. 23.1%; P <0.05). The agreement between the two assays was poor (69.6%, k=0.190). Of the 18 cases with positive Easy Test TB, six (33%) showed negative QFT results. The combination of Easy Test TB and QFT had a significantly higher sensitivity than single QFT (75.6%, vs. 67.9%; P =0.031). Conclusions: The combination of Easy Test TB and QFT could be used to aid in a rapid diagnosis and early treatment of TB.

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