지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 35 - 42 (8page)
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초록· 키워드
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Background: Measurements of serum anti-thyroglobulin antibody (anti-Tg) and anti-thyroid peroxidase antibody (anti-TPO) are important for the diagnosis of autoimmune thyroid diseases. Although ELISA is most commonly used for the detection of anti-thyroid autoantibodies, other methods like particle agglutination assay (PA) or radioimmunoassay (RIA) are still being used in clinical laboratories. There are few studies about the comparison between PA and ELISA, and we evaluated the validity of these assays in this study.
Methods: We have used three methods, PA (Fujirebio Inc.), ELISA-1 (Zeus Scientific Inc.), and ELISA-2 (Orgentec Diagnostika) for the measurements of titers or concentrations of anti-thyroid autoantibodies. A total of 212 patients belonging to six different disease groups were tested: 40 patients for anti-Tg only, 64 for anti-TPO (or anti-microsome) only, and 108 for both antibodies. All test results were compared with each other in six disease groups.
Results: Concordance of positive or negative results was obtained in 78.5-97.3% of the samples tested, and positive rates of three methods were similar in autoimmume thyroid disease group. In the comparable concentration range, the correlation coefficients were 0.328-0.820 between the two ELISAs or between ELISA and PA.
Conclusions: Positive or negative decisions by three assay systems have high concordance rates, and antibody levels measured by three methods correlate well in the comparable concentration range. The ELISA-1 shows less non-specific reactions, better discrimination in low level of autoantibodies, and the highest positive rate in autoimmume thyroid disease group.
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참고문헌 (19)
참고문헌 신청
Cayzer I / 1978 / An evaluation of two new hemagglutination tests for the rapid diagnosis of autoimmune thyroid diseases / J Clin Pathol 31 : 1147 ~ 1151
Czarnocka B / 1985 / Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases / FEBS Lett 190 :
Engler H / 1989 / Assessment of antithyroglobulin and antimicrosomal autoantibodies in patients with autoimmune thyroid disease: comparison of haemagglutination assay, enzym
Engler H / 1994 / Anti-thyroid peroxidase (anti-TPO) an tibodies in thyroid diseases, non-thyroidal illness and controls. Clinical validity of a new commercial method for de
Feldt-Rasmussen U / 1991 / Anti-thyroid peroxidase antibodies in thyroid disorders and non-thyroid autoimmune diseases / Autoimmunity 9 : 245 ~ 254
Czarnocka B / 1985 / Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases / FEBS Lett 190 :
Engler H / 1989 / Assessment of antithyroglobulin and antimicrosomal autoantibodies in patients with autoimmune thyroid disease: comparison of haemagglutination assay, enzym
Engler H / 1994 / Anti-thyroid peroxidase (anti-TPO) an tibodies in thyroid diseases, non-thyroidal illness and controls. Clinical validity of a new commercial method for de
Feldt-Rasmussen U / 1991 / Anti-thyroid peroxidase antibodies in thyroid disorders and non-thyroid autoimmune diseases / Autoimmunity 9 : 245 ~ 254
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