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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 17 - 24 (8page)
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초록· 키워드
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Background : This study was designed to characterize urinary isolates of Escherichia coli that produce extended-spectrum β-lactamases (ESBLs) and to determine the prevalence of other antimicrobial resistance genes.
Methods : A total of 264 non-duplicate clinical isolates of E. coli were recovered from urine specimens in a tertiary-care hospital in Busan in 2005. Antimicrobial susceptibility was determined by disk diffusion and agar dilution methods, ESBL production was confirmed using the double-disk
synergy (DDS) test, and antimicrobial resistance genes were detected by direct sequencing of PCR amplification products. E. coli isolates were classified into four phylogenetic biotypes according to the presence of chuA, yjaA, and TSPE4.
Results : DDS testing detected ESBLs in 27 (10.2%) of the 264 isolates. The most common type of ESBL was CTX-M-15 (N=14), followed by CTX-M-3 (N=8) and CTX-M-14 (N=6). All of the ESBLproducing isolates were resistant to ciprofloxacin. PCR experiments detected genes encoding DHA-
1 and CMY-10 AmpC β-lactamases in one and two isolates, respectively. Also isolated were 5 isolates harboring 16S rRNA methylases, 2 isolates harboring Qnr, and 19 isolates harboring AAC(6’)- Ib-cr. Most ESBL-producing isolates clustered within phylogenetic groups B2 (N=14) and D (N=7).
Conclusion : CTX-M enzymes were the dominant type of ESBLs in urinary isolates of E. coli, and ESBL-producing isolates frequently contained other antimicrobial resistance genes. More than half of the urinary E. coli isolates harboring CTX-M enzymes were within the phylogenetic group B2.
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참고문헌 (22)
참고문헌 신청
Baudry PJ / 2008 / Comparison of antimicrobial resistance profiles among extended-spectrum β-lactamase-producing and acquired AmpC β-lactamase-producing Escherichia coli i
Bonnet R / 2004 / Growing group of extended-spectrum β-lactamases: the CTX-M enzymes / Antimicrob Agents Chemother 48 : 1 ~ 14
Cattoir V / 2007 / Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates / J Antimicrob Chemother 60 : 39
Clinical and Laboratory Standards Institute / 2007 / Performance standards for antimicrobial susceptibility testing; seventeenth informational supplement: Approved Standard M100-S17,
Doi Y / 2007 / 16S ribosomal RNA methylation: emerging resistance mechanism against aminoglycosides / Clin Infect Dis 45 : 88 ~ 94
Bonnet R / 2004 / Growing group of extended-spectrum β-lactamases: the CTX-M enzymes / Antimicrob Agents Chemother 48 : 1 ~ 14
Cattoir V / 2007 / Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates / J Antimicrob Chemother 60 : 39
Clinical and Laboratory Standards Institute / 2007 / Performance standards for antimicrobial susceptibility testing; seventeenth informational supplement: Approved Standard M100-S17,
Doi Y / 2007 / 16S ribosomal RNA methylation: emerging resistance mechanism against aminoglycosides / Clin Infect Dis 45 : 88 ~ 94
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