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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 31 - 37 (7page)
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초록· 키워드
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Background: Methylmercury is an organic form of mercury that is highly toxic to humans. Here, we present and establish a novel method to detect methylmercury concentrations in the blood of Koreans.
Methods: Methylmercury concentration was analyzed with an automated methylmercury analytic system (MERX, Brooks Rand Co., USA) using cold vapor atomic fluorescence spectrophotometry (CVAFS). A variety of biological materials were digested in methanolic potassium hydroxide solution. The analysis method was validated by examination of certified reference material (955c, National Institute of Standard and Technology, USA). We randomly selected 30 Korean adults (age 20 yr or older) to analyze total blood mercury and methylmercury concentrations.
Results: The detection limit and methylmercury recovery rate using this method were 0.1 pg/L and, 99.19% (range: 89.33-104.89%), respectively. The mean blood concentration of methylmercury was 4.54±2.15 μg/L (N=30). The mean proportion of methylmercury to the total mercury concentration was 78.27% (range: 41.37-98.80%).
Conclusions: This study is the first report to analyze blood methylmercury concentration using CVAFS in Korea. We expect that this method will contribute to the evaluation of mercury exposure and the assessment of the toxicological impact of mercury in future studies.
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참고문헌 (17)
참고문헌 신청
Berglund M / 2005 / Inter- individual variations of human mercury exposure biomarkers: a cross-sectional assessment / Environ Health 3 : 4 ~ 20
De Wild JF / / Determination of methyl mercury by aqueous phase ethylation, followed by gas chromatographic separation with cold vapor atomic fluorescence detection. U.S. Geological
Grandjean P / 1994 / Methylmercury: significance of intrauterine and postnatal exposures / Clin Chem 40 : 1395 ~ 1400
Harada M / 1995 / Minamata disease: methylmercury poisoning in Japan caused by environmental pollution / Crit Rev Toxicol 25 : 1 ~ 24
Kim GB / 2007 / Comparison study between total blood mercury and methylmercury / Proceedings of Annual meeting of Korean Society of Health Education and promotion 2 : 345 ~ 348
De Wild JF / / Determination of methyl mercury by aqueous phase ethylation, followed by gas chromatographic separation with cold vapor atomic fluorescence detection. U.S. Geological
Grandjean P / 1994 / Methylmercury: significance of intrauterine and postnatal exposures / Clin Chem 40 : 1395 ~ 1400
Harada M / 1995 / Minamata disease: methylmercury poisoning in Japan caused by environmental pollution / Crit Rev Toxicol 25 : 1 ~ 24
Kim GB / 2007 / Comparison study between total blood mercury and methylmercury / Proceedings of Annual meeting of Korean Society of Health Education and promotion 2 : 345 ~ 348
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