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자료유형
학술저널
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대한진단검사의학회 Annals of Laboratory Medicine Annals of Laboratory Medicine 제33권 제2호
발행연도
2013.1
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97 - 104 (8page)

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Background: Therapy-related myeloid neoplasms (t-MN) occur as late complications of cytotoxic therapy. This study reviewed clinical and cytogenetic characteristics of patients with t-MN at a single institution in Korea. Methods: The study subjects included 39 consecutive patients diagnosed with t-MN. Each subject’s clinical history of previous diseases, treatments, and laboratory data was reviewed, including cytogenetics. The primary diagnosis was hematologic malignancy in 14 patients and solid tumor in 25 patients. Results: Therapy-related acute myeloid leukemia (t-AML, 66.7%) was found to be more common than therapy-related myelodysplastic syndrome (t-MDS). Primary hematologic malignancies that were commonly implicated included mature B-cell neoplasm and acute leukemia. Breast cancer was the most common primary solid tumor. The mean time interval from cytotoxic therapy initiation to t-MN detection was 49 months. Chromosomal aberrations were observed in 35 patients, and loss of chromosome 5, 7, or both accounted for 41% of all cases. Balanced rearrangements occurred in 13 patients; these patients showed shorter latency intervals (mean, 38 months) than patients with loss of chromosome 5 or 7(mean, 61 months). Conclusions: In this study, we determined the clinical and cytogenetic characteristics of Korean patients with t-MN. Although our results were generally consistent with those of previous reports, we found that t-MN resulting from de novo leukemia was common and that t-AML was more common than t-MDS at presentation. Multi-institutional studies involving a larger number of patients and additional parameters are required to investigate the epidemiology, genetic predisposition, and survival rate of t-MN in Korea.
#Therapy-related neoplasms #Myelodysplastic syndrome #Acute myeloid leukemia #Cytogenetics #Korea #Therapy-related neoplasms #Myelodysplastic syndrome #Acute myeloid leukemia #Cytogenetics #Korea

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참고문헌 (22)

참고문헌 신청
Arana-Yi C / 2008 / Therapyrelated myelodysplastic syndrome and acute myeloid leukemia following treatment of acute myeloid leukemia: possible role of cytarabine / Leuk Res google schola Estey E / 2006 / Acute myeloid leukaemia / Lancet 368 : 1894 ~ 1907 google schola Hur M / 1999 / Four cases of therapy- related leukemia / J Korean Med Sci 14 : 327 ~ 329 google schola Hyoeun Shim / 2010 / Therapy-related acute leukemia in breast cancer patients: twelve cases treated with a topoisomerase inhibitor / Blood Research 45 (3) : 177 ~ 182 google schola Jung CL / 2011 / CKIT mutation in therapy-related acute myeloid leukemia with MLLT3/MLL chimeric transcript from t(9;11)(p22;q23) / Ann Clin Lab Sci google schola

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