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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 209 - 214 (6page)
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초록· 키워드
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Background: The clinical usefulness of flow cytometry (FCM) for the diagnosis of leptomeningeal diseases (LMD) in non-Hodgkin lymphomas has been suggested in previous studies but needs to be further validated. With this regards, we evaluated the use of FCM for LMD in a series of Korean patients with non-Hodgkin lymphoma.
Methods: FCM and cytomorphology were conducted using samples obtained from clinically suspected LMD patients, follow-up LMD patients, and those with high risk of developing tumorigenic diseases. We then compared results of FCM and cytomorphology. In total, 55 and 47 CSF samples were analyzed by FCM and cytomorphology, respectively.
Results: Of the samples analyzed, 25.5% (14/55) and 12.8% (6/47) were positive by FCM and cytomorphology, respectively. No samples were determined as negative by FCM but positive by cytomorphology. Seven patients were positive only by FCM and negative by cytomorphology, and six among them were clinically confirmed to have LMD either by follow-up cytomorphology or imaging study.
Conclusions: We observed a high detection rate of tumor cells by FCM compared with cytomorphology. FCM study can be useful in early sensitive detection of LMD.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Wilson WH / 2014 / Detection and outcome of occult leptomeningeal disease in diffuse large B-cell lymphoma and Burkitt lymphoma / Haematologica 99:1228~1235
Hill QA / 2006 / CNS prophylaxis in lymphoma: who to target and what therapy to use / Blood Rev 20:319~332
Woo J / 2014 / Recent advancements of flow cytometry: new applications in hematology and oncology / Expert Rev Mol Diagn 14:67~81
Craig FE / 2008 / Flow cytometric immunophenotyping for hematologic neoplasms / Blood 111:3941~3967
de Graaf MT / 2011 / Flow cytometric characterization of cerebrospinal fluid cells / Cytometry B Clin Cytom 80:271~281
Hill QA / 2006 / CNS prophylaxis in lymphoma: who to target and what therapy to use / Blood Rev 20:319~332
Woo J / 2014 / Recent advancements of flow cytometry: new applications in hematology and oncology / Expert Rev Mol Diagn 14:67~81
Craig FE / 2008 / Flow cytometric immunophenotyping for hematologic neoplasms / Blood 111:3941~3967
de Graaf MT / 2011 / Flow cytometric characterization of cerebrospinal fluid cells / Cytometry B Clin Cytom 80:271~281
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