지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 39 - 45 (7page)
이용수
초록· 키워드
오류제보하기
Background: Given that YKL-40 is a known marker of inflammation, we sought to determine its association with urinary tract infection (UTI) in febrile children. Methods: In total, 44 children aged 0 to 24 months with febrile UTI and 35 age- and sex-matched controls with fever from other causes were enrolled in the study. ELISA was performed to determine the level of YKL-40 in urine collected from each child. Results: The ratio of urinary YKL-40 to creatinine (Cr) was higher in the children with a UTI than in the controls (P<0.001). The area under the ROC curve for detecting UTI was 0.88 for the urinary YKL-40/Cr ratio, 0.86 for pyuria, and 0.71 for positive nitrite on urinalysis. We applied a cut-off value of 125.23 pg/mg to urinary YKL-40/Cr for detecting UTI. Eight of nine children in the control group with pyuria had urinary YKL-40/Cr levels lower than 125.23 pg/mg, and the one child in the UTI group without pyuria or positive nitrite had a urinary YKL-40/Cr level greater than 125.23 pg/mg. Conclusions: Determining the levels of urinary YKL-40/Cr may help identify true cases of UTI in febrile young children, especially when they have pyuria but not nitrite, or have neither pyuria nor nitrite in the urine.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Johansen JS / 1992 / Identification of proteins secreted by human osteoblastic cells in culture / J Bone Miner Res 7:501~512
Volck B / 1998 / YKL-40, a mammalian member of the chitinase family, is a matrix protein of specific granules in human neutrophils / Proc Assoc Am Physicians 110:351~360
Lee CG / 2011 / Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury / Annu Rev Physiol 73:479~501
Johansen JS / 2006 / Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer / Dan Med Bull 53:172~209
Prakash M / 2013 / Diverse pathological implications of YKL-40: answers may lie in ‘outside-in' signaling / Cell Signal 25:1567~1573
Volck B / 1998 / YKL-40, a mammalian member of the chitinase family, is a matrix protein of specific granules in human neutrophils / Proc Assoc Am Physicians 110:351~360
Lee CG / 2011 / Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury / Annu Rev Physiol 73:479~501
Johansen JS / 2006 / Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer / Dan Med Bull 53:172~209
Prakash M / 2013 / Diverse pathological implications of YKL-40: answers may lie in ‘outside-in' signaling / Cell Signal 25:1567~1573
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