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Objective To identify risk factors for developing a vertebral refracture after percutaneous vertebroplasty. Method A retrospective analysis of 60 patients who had undergone percutaneous vertebroplasty between January 2008 and April 2010 was conducted. All patients were observed for a 1 year follow-up period, and fracture was defined when it was both clinically reported and radiographically confirmed. Twenty-seven patients with a refractured vertebra and 33 patients without a refracture were included. Of the 60 patients, 20 presented with a refracture from a cemented vertebra, whereas the remaining 40 patients did not. Clinical, imaging and procedurerelated factors for each group were analyzed by the Fisher’s exact, chi-square, and the Mann–Whitney U-tests. Results Local kyphotic angle and sagittal index were significant as a result of researching various risk factors related to vertebral refracture (p<0.001, p<0.001, respectively) and refracture from a cemented vertebra itself (p=0.004, p<0.001, respectively). Other factors were not significant. Conclusion Patients who had a high preoperative local kyphotic angle and a high sagittal index required a close follow-up and attention.

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