지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 388 - 397 (10page)
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초록· 키워드
오류제보하기
Background: Proenkephalin (PENK) has been suggested as a novel biomarker for kidney function. We investigated the diagnostic and prognostic utility of plasma PENK in comparison with neutrophil gelatinase-associated lipocalin (NGAL) and estimated glomerular filtration rates (eGFR) in septic patients.
Methods: A total of 167 septic patients were enrolled: 99 with sepsis, 37 with septic shock, and 31 with suspected sepsis. PENK and NGAL concentrations were measured and GFR was estimated by using the isotope dilution mass spectrometry traceable-Modification of Diet in Renal Disease (MDRD) Study and three Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations: CKD-EPICr, CDK-EPICysC, and CKD-EPICr-CysC. The PENK, NGAL, and eGFR results were compared according to sepsis severity, presence or absence of acute kidney injury (AKI), and clinical outcomes.
Results: The PENK, NGAL, and eGFR results were significantly associated with sepsis severity and differed significantly between patients with and without AKI only in the sepsis group (all P<0.05). PENK was superior to NGAL in predicting AKI (P=0.022) and renal replacement therapy (RRT) (P=0.0085). Regardless of the variable GFR category by the different eGFR equations, PENK showed constant and significant associations with all eGFR equations. Unlike NGAL, PENK was not influenced by inflammation and predicted the 30-day mortality.
Conclusions: PENK is a highly sensitive and objective biomarker of AKI and RRT and is useful for prognosis prediction in septic patients. With its diagnostic robustness and predictive power for survival, PENK constitutes a promising biomarker in critical care settings including sepsis.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Alobaidi R / 2015 / Sepsis-associated acute kidney injury / Semin Nephrol 35 : 2 ~ 11
Dellinger RP / 2013 / Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012 / Crit Care Med 41 : 580 ~ 637
Honore PM / 2015 / Prevention and treatment of sepsis-induced acute kidney injury: an update / Ann Intensive Care 5 : 51 ~ 60
Hoste EA / 2005 / Assessment of renal function in recently admitted critically ill patients with normal serum creatinine / Nephrol Dial Transplant 20 : 747 ~ 753
Ichai C / 2016 / Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies) / Ann Intensive Care 6 : 48 ~
Dellinger RP / 2013 / Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012 / Crit Care Med 41 : 580 ~ 637
Honore PM / 2015 / Prevention and treatment of sepsis-induced acute kidney injury: an update / Ann Intensive Care 5 : 51 ~ 60
Hoste EA / 2005 / Assessment of renal function in recently admitted critically ill patients with normal serum creatinine / Nephrol Dial Transplant 20 : 747 ~ 753
Ichai C / 2016 / Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies) / Ann Intensive Care 6 : 48 ~
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