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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 667 - 675 (9page)
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초록· 키워드
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Objective To investigate the effect of pulsed radiofrequency (PRF) applied proximal to the injured peripheral nerve on the expression of tumor necrosis factor-α (TNF-α) in a neuropathic pain rat model.Methods Nineteen male Sprague-Dawley rats were used in the study. All rats underwent chronic constriction injury (CCI) procedure. After 7 days of CCI, withdrawal frequency of affected hind paw to mechanical stimuli and withdrawal latency of affected hind paw to heat stimulus were measured. They were randomly divided into two groups: group A, CCI group (n=9) and group B, CCI treated with PRF group (n=10). Rats of group B underwent PRF procedure on the sciatic nerve. Withdrawal frequency and withdrawal latency were measured at 12 hours, and 7 days after PRF. Immunohistochemistry and Western blot analysis were performed using a TNF-α antibody.Results Before PRF, withdrawal frequency and withdrawal latency were not different in both groups. After PRF, withdrawal frequency decreased and withdrawal latency prolonged over time in group B. There was significant interaction between time and group for each withdrawal frequency and withdrawal latency. Group B showed decreased TNF-α immunoreactivity of the spinal cord and sciatic nerve at 7 days.Conclusion PRF applied proximal to the peripheral nerve injury is potentially helpful for the reduction of neuropathic pain by neuromodulation of inflammatory markers.
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등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
Clatworthy AL / 1995 / Role of peri-axonal inflammation in the development of thermal hyperalgesia and guarding behavior in a rat model of neuropathic pain / Neurosci Lett 184:5~8
Wagner R / 1996 / Schwann cells produce tumor necrosis factor alpha: expression in injured and noninjured nerves / Neuroscience 73:625~629
Wagner R / 1996 / Endoneurial injection of TNFalpha produces neuropathic pain behaviors / Neuroreport 7:2897~2901
Kukkar A / 2013 / Neuropathic pain-attenuating potential of aliskiren in chronic constriction injury model in rats / J Renin Angiotensin Aldosterone Syst 14:116~123
Wagner R / 1998 / Anti-inflammatory interleukin-10 therapy in CCI neuropathy decreases thermal hyperalgesia, macrophage recruitment, and endoneurial TNF-alpha expression / Pain 74:35~42
Wagner R / 1996 / Schwann cells produce tumor necrosis factor alpha: expression in injured and noninjured nerves / Neuroscience 73:625~629
Wagner R / 1996 / Endoneurial injection of TNFalpha produces neuropathic pain behaviors / Neuroreport 7:2897~2901
Kukkar A / 2013 / Neuropathic pain-attenuating potential of aliskiren in chronic constriction injury model in rats / J Renin Angiotensin Aldosterone Syst 14:116~123
Wagner R / 1998 / Anti-inflammatory interleukin-10 therapy in CCI neuropathy decreases thermal hyperalgesia, macrophage recruitment, and endoneurial TNF-alpha expression / Pain 74:35~42
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