지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Purpose : The aim of this study is to evaluate a possibility of clinical application for the effects of low intensity ultrasound stimulation (LIUS) in morphological characteristics (i.e., structure, bone mineral density) of bone on osteoporotic fracturesprevention.
Materials and Methods : Eight virgin 14-week-old ICR mice (approximate weight 25g) were used and ovariectomized (OVX) to induce osteoporosis. Right tibia (US) for each mouse served as the LIUS (1.5MHz frequency, 1.0 kHz pulse repetition on frequency, 30mW/cm2㎠ intensity, 200㎲ pulse length, and stimulation for 20 minutes a day and 5 days a week over a 6-week period). Left tibia (CON) for each mouse served as the non-stimulated controls. Structural parameters and bone mineral density (g/㎤) on trabecular bone of tibiae were calculated and measured from images derived in-vivo micro computed tomography (micro-CT) at 0 week and after 6weeks.
Results : The BV/TV and Tb.N in US group were significantly bigger than those in CON group. The Tb.Pf in US group, moreover, was significantly smaller than that in CON group (p＜0.05).For the others structural parameters and BMD, however, there were no significant difference between US group and CON group (p＞0.05).
Conclusion : The LIUS might prevent bone loss and keep bone connectivity in osteoporotic bones. Therefore, the LIUS might prevent effectively the osteoporotic fractures in clinics.
목차
등록된 정보가 없습니다.
참고문헌 (11)
참고문헌 신청
/ 2007 / The Korean Society of Bone Metabolism: Physician`s guideline for osteoporosis / Seoheung
Carvalho DCL / 2004 / The action of low-intensity pulsed ultrasound in bones of osteopenic rats / Artificial Organs 28 : 114 ~ 118
Clase L / 2007 / The enhancement of bone regeneration by ultrasound / Progress in Biophysics and Molecular Biology 93 : 384 ~ 398
Cowin S / 2000 / Bone mechanics handbook / CRC press : 1 ~ 32
Lacey JJ / 2002 / Menopausal hormone replacement therapy and risk of ovarian cancer / JAMA : the journal of the American Medical Association 288 : 334 ~ 341
Carvalho DCL / 2004 / The action of low-intensity pulsed ultrasound in bones of osteopenic rats / Artificial Organs 28 : 114 ~ 118
Clase L / 2007 / The enhancement of bone regeneration by ultrasound / Progress in Biophysics and Molecular Biology 93 : 384 ~ 398
Cowin S / 2000 / Bone mechanics handbook / CRC press : 1 ~ 32
Lacey JJ / 2002 / Menopausal hormone replacement therapy and risk of ovarian cancer / JAMA : the journal of the American Medical Association 288 : 334 ~ 341
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