지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 766 - 776 (11page)
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초록· 키워드
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Objective To investigate the analgesic effect of transcranial direct current stimulation (tDCS) over the primary motor (M1), dorsolateral prefrontal cortex (DLPFC), and sham tDCS in patients with painful diabetic polyneuropathy (PDPN).Methods Patients with PDPN (n=60) were divided randomly into the three groups (n=20 per group). Each group received anodal tDCS with the anode centered over the left M1, DLPFC, or sham stimulation for 20 minutes at intensity of 2 mA for 5 consecutive days. A blinded physician rated the patients’ pain using a visual analog scale (VAS), Clinical Global Impression (CGI) score, anxiety score, sleep quality, Beck Depression Inventory (BDI), and the pain threshold (PT) to pressure.Results After the tDCS sessions, the M1 group showed a significantly greater reduction in VAS for pain and PT versus the sham and DLPFC groups (p<0.001). The reduction in VAS for pain was sustained after 2 and 4 weeks of follow-up in the M1 group compared with the sham group (p<0.001, p=0.007). Significant differences were observed among the three groups over time in VAS for pain (p<0.001), CGI score (p=0.01), and PT (p<0.001). No significant difference was observed among the groups in sleep quality, anxiety score, or BDI score immediately after tDCS.Conclusion Five daily sessions of tDCS over the M1 can produce immediate pain relief, and relief 2- and 4-week in duration in patients with PDPN. Our findings provide the first evidence of a beneficial effect of tDCS on PDPN.
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참고문헌 (24)
참고문헌 신청
American Diabetes Association. / 2010 / Diagnosis and classification of diabetes mellitus / Diabetes Care 33 (Suppl 1) : S62 ~ S69
Baron R. / 2006 / Mechanisms of disease : neuropathic pain : a clinical perspective / Nat Clin Pract Neurol 2 : 95 ~ 106
Bastyr EJ 3rd. / 2005 / Development and validity testing of the neuropathy total symptom score-6 : questionnaire for the study of sensory symptoms of diabetic peripheral neu
Beck AT. / 1996 / Comparison of Beck Depression Inventories-IA and-II in psychiatric outpatients / J Pers Assess 67 : 588 ~ 597
Boggio PS. / 2008 / Modulatory effects of anodal transcranial direct current stimulation on perception and pain thresholds in healthy volunteers / Eur J Neurol 15 : 1124 ~ 1
Baron R. / 2006 / Mechanisms of disease : neuropathic pain : a clinical perspective / Nat Clin Pract Neurol 2 : 95 ~ 106
Bastyr EJ 3rd. / 2005 / Development and validity testing of the neuropathy total symptom score-6 : questionnaire for the study of sensory symptoms of diabetic peripheral neu
Beck AT. / 1996 / Comparison of Beck Depression Inventories-IA and-II in psychiatric outpatients / J Pers Assess 67 : 588 ~ 597
Boggio PS. / 2008 / Modulatory effects of anodal transcranial direct current stimulation on perception and pain thresholds in healthy volunteers / Eur J Neurol 15 : 1124 ~ 1
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