지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 186 - 193 (8page)
이용수
초록· 키워드
오류제보하기
Objective: To find out whether electrical stimulation affects intracellular signaling mechanisms that link the biochemical and mechanical events of smooth muscle contraction.
Method: A total of 31 adult Sprague-Dawley female rats were divided into 3 groups: control group, spinal cord injury (SCI) only group, and spinal cord injury with electrical stimulation (SCI＋ES) group. Complete spinal cord transection was performed surgically at T10 cord level. The electrode for electrical stimulation was implanted into sacral spinal cord region (S2-4). Electrical stimulation was applied 4 hours per day from the day of operation.
Results: In SCI＋ES group, the weights of fecal pellet were significantly higher from the 3rd day of post-operation to the 6th day than the SCI only group. The numbers of pERK 1/2 immunoreactive cells significantly increased in all colon segments of the SCI＋ES group but had decreased in the SCI only group. Western blot showed the stronger bands of phosphorylated ERK1/2 in all colon segments and also phosphorylated caldesmon in mid or distal colon segments in the SCI＋ES group.
Conclusion: These results suggest that electrical stimulation to sacral plexus region activate phosphorylation of ERK1/2 and caldesmon which leads to improvement of bowel function by promotion of secretion or motility in the colon.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Basso DM / 1996 / Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection / Exp Neurol 139 : 244 ~ 256
Benazzouz A / 1993 / Reversal of rigidity and improvement in motor performance by subthalamic high-frequency stimulation in MPTP-treated monkeys / Eur J Neurosci 5 : 382 ~ 38
Brindley GS / 1982 / Sacral anterior root stimulators for bladder control in paraplegia / Paraplegia 20 : 365 ~ 381
Buresi MC / 2002 / Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclo- oxygenase-dependent pathway
Chartier-Kastler EJ / 2001 / Urodynamic monitoring during percutaneous sacral nerve neurostimulation in patients with neurogenic detrusor hyperreflexia / Neurourol Urodyn 20
Benazzouz A / 1993 / Reversal of rigidity and improvement in motor performance by subthalamic high-frequency stimulation in MPTP-treated monkeys / Eur J Neurosci 5 : 382 ~ 38
Brindley GS / 1982 / Sacral anterior root stimulators for bladder control in paraplegia / Paraplegia 20 : 365 ~ 381
Buresi MC / 2002 / Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclo- oxygenase-dependent pathway
Chartier-Kastler EJ / 2001 / Urodynamic monitoring during percutaneous sacral nerve neurostimulation in patients with neurogenic detrusor hyperreflexia / Neurourol Urodyn 20
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