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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제9권 제2호
- 발행연도
- 2011.1
- 수록면
- 67 - 72 (6page)
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Objective: In humans, a single exposure to phencyclidine (PCP) can induce a schizophrenia-like psychosis which can persist for up to two weeks. In rats, an acute dose of PCP increases dopaminergic activity and causes changes in dopamine related behaviours some of which are sexually dimorphic. To better understand the effects of PCP on dopamine receptor adaptations in the short term we examined dopamine D1-like receptors (D1R) and D2-like receptors (D2R) in the mesolimbic and nigrostriatal dopamine pathways, 4 hours after exposure to PCP in female rats.
Methods: Animals received a single dose of 40 mg/kg PCP and were sacrificed 4 hours later. In vitro autoradiography was carried out using [^3H] SCH 23390 and [^3H] raclopride that target D1R and D2R respectively, in cryostat brain sections.
Results: Two way analysis of variance (ANOVA), revealed an overall effect of PCP treatment (F [1,63]=9.065; p=0.004) on D1R binding with an 18% decrease (p＜0.01) in binding in the medial caudate putamen. PCP treatment also had an overall effect on D2R binding (F [1,47]=5.450; p=0.024) and a trend for an increase in D2R binding across all the brain regions examined.
Conclusion: These results suggest opposing D1R and D2R adaptations in striatal subregions of female rats following acute exposure to PCP that may occur through indirect mechanisms.
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참고문헌 (23)
참고문헌 신청
Creese I / 1981 / Receptor adaptations to centrally acting drugs / Annu Rev Pharmacol Toxicol 21 : 357 ~ 391
Dawson TM / 1986 / Wamsley JK. D-1 dopamine receptors in the rat brain: a quantitative autoradiographic analysis / J Neurosci 6 : 2352 ~ 2365
Dunn MJ / 2007 / SCH 23390 and alpha-flupenthixol but not haloperidol attenuate acute phencyclidine-induced disruption of conditional discrimination performance / Psychophar
Frederick DL / 1995 / Acute behavioral effects of phencyclidine on rhesus monkey performance in an operant test battery / Pharmacol Biochem Behav 52 : 789 ~ 797
Geyer MA / 2001 / Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review / Psychopharmacology (Berl) 156 :
Dawson TM / 1986 / Wamsley JK. D-1 dopamine receptors in the rat brain: a quantitative autoradiographic analysis / J Neurosci 6 : 2352 ~ 2365
Dunn MJ / 2007 / SCH 23390 and alpha-flupenthixol but not haloperidol attenuate acute phencyclidine-induced disruption of conditional discrimination performance / Psychophar
Frederick DL / 1995 / Acute behavioral effects of phencyclidine on rhesus monkey performance in an operant test battery / Pharmacol Biochem Behav 52 : 789 ~ 797
Geyer MA / 2001 / Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review / Psychopharmacology (Berl) 156 :
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