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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제15권 제2호
- 발행연도
- 2017.1
- 수록면
- 146 - 152 (7page)
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초록· 키워드
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Objective: To investigate pathological conditions that act as sources of pro-inflammatory cytokines and cytotoxic substances to examine telomere length (TL) in patients with either early (duration of illness [DI] ≤5 years) or chronic (DI ＞5 years) psychosis using T lymphocytes.
Methods: Based on these factors and the important role that T lymphocytes play in inflammation, the present study measured the TL of T lymphocytes in patients with either early or chronic psychosis. Additionally, smoking, metabolic syndrome, depression, and cognitive functioning were assessed to control for confounding effects.
Results: TL was significantly longer in patients with early and chronic psychosis than in healthy control subjects and, moreover, the significance of these findings remained after controlling for age, smoking, metabolic syndrome, DI, chlorpromazine-equivalent dose, and cognitive functioning (F=9.57, degree of freedom=2, p＜0.001). Additionally, the DI, chlorpromazine-equivalent doses, and the five-factor scores of the Positive and Negative Syndrome Scale were not significantly correlated with the TL of T lymphocytes in either all patients or each psychosis group.
Conclusion: Possible mechanisms underlying the effects of antipsychotic medications on telomerase are discussed in the present study, but further studies measuring both telomerase activity and TL using a prospective design will be required.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Blackburn EH / 2005 / Telomeres and telomerase : their mechanisms of action and the effects of altering their functions / FEBS Lett 579 : 859 ~ 862
Blasco MA / 2005 / Telomeres and human disease: ageing, cancer and beyond / Nat Rev Genet 6 : 611 ~ 622
Brait VH / 2012 / Importance of T lymphocytes in brain injury, immunodeficiency, and recovery after cerebral ischemia / J Cereb Blood Flow Metab 32 : 598 ~ 611
Brydon L / 2012 / Hostility and cellular aging in men from the Whitehall II cohort / Biol Psychiatry 71 : 767 ~ 773
Epel ES / 2004 / Accelerated telomere shortening in response to life stress / Proc Natl Acad Sci U S A 101 : 17312 ~ 17315
Blasco MA / 2005 / Telomeres and human disease: ageing, cancer and beyond / Nat Rev Genet 6 : 611 ~ 622
Brait VH / 2012 / Importance of T lymphocytes in brain injury, immunodeficiency, and recovery after cerebral ischemia / J Cereb Blood Flow Metab 32 : 598 ~ 611
Brydon L / 2012 / Hostility and cellular aging in men from the Whitehall II cohort / Biol Psychiatry 71 : 767 ~ 773
Epel ES / 2004 / Accelerated telomere shortening in response to life stress / Proc Natl Acad Sci U S A 101 : 17312 ~ 17315
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