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논문 기본 정보

자료유형
학술저널
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저널정보
대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제11권 제2호
발행연도
2013.1
수록면
80 - 88 (9page)

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Objective: To examine the prevalence of metabolic syndrome and its risk factors in a large group of schizophrenic patients. Methods: Sociodemographic and treatment data were collected from medical records of 1,103 inpatients and outpatients treated for schizophrenia at Seoul National Hospital in Seoul, Korea. Anthropometric measurement and blood testing were conducted for collection of physical and biochemical data and diagnosis of metabolic syndrome. Data for metabolic syndrome prevalence were compared by sex, age, metabolic syndrome markers present, treatment of markers, and types of antipsychotics and individual drug agents used. Results: Mean prevalence of metabolic syndrome in all subjects was 43.9% and 40.1% according to adapted Adult Treatment Panel III (ATP-IIIa) and International Diabetes Federation criteria, respectively. No significant differences were found in prevalence according to ATP-IIIa criteria between men (42.6%) and woman (45.9%). A trend toward higher prevalence with age was observed for both sexes until 50 years, followed by a continued increase for women but a decrease for men. Use of a combination of atypical antipsychotics was associated with the highest metabolic syndrome prevalence and use of aripiprazole with the lowest. High percentages of subjects with hypertension and dyslipidemia were not being treated for these conditions. Conclusion: Despite their higher prevalence in schizophrenic patients, metabolic syndrome and its markers are not being adequately managed in these patients. Treatment of schizophrenic patients requires attention to not only their psychiatric conditions but also associated medical conditions by individual health care practitioners and hospitals as well as the public health care sector as a whole.
#Antipsychotic agents #Metabolic syndrome #Schizophrenia.

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참고문헌 (22)

참고문헌 신청
Alberti KG / 1998 / Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional google schola Allison DB / 1999 / Antipsychotic-induced weight gain: a comprehensive research synthesis / Am J Psychiatry 156 : 1686 ~ 1696 google schola Allison DB / 1999 / The distribution of body mass index among individuals with and without schizophrenia / J Clin Psychiatry 60 : 215 ~ 220 google schola Allison DB / 2001 / Antipsychotic-induced weight gain: a review of the literature / J Clin Psychiatry 62 (Suppl 7) : 22 ~ 31 google schola American Diabetes Association; American Psychiatric Association; American Association of Clinical Endocrinologists; North American Association for the Study of Obesity. / 200 google schola

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