지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제15권 제1호
- 발행연도
- 2017.1
- 수록면
- 40 - 46 (7page)
이용수
초록· 키워드
오류제보하기
Objective: Electroconvulsive therapy (ECT) is used in the treatment of many psychiatric diseases and this therapy may be effective on antioxidant defence system. In this study, we aimed to evaluate the effects of ECT on oxidative stress.
Methods: Fourteen major depression, 11 schizophrenia and 8 bipolar affective disorder patients diagnosed and received ECT treatment, and 37 healthy volunteers enrolled in the study. ECT was applied to all patients. Before ECT, after the first and last ECTs, serum samples were obtained. Serum total antioxidant status (TAS), total oxidant status (TOS), and calculated oxidative stress index (OSI) were measured in patients before and after ECTs.
Results: TOS values before ECT were higher in major depression (p=0.005) and schizophrenia (p=0.001) groups compared to the control group. TAS values were lower in major depression (p=0.0001), schizophrenia (p=0.004), bipolar affective disorder (p=0.004) groups compared to the controls. Also OSI values were higher in major depression (p=0.0001), schizophrenia (p=0.001), bipolar affective disorder (p=0.009) groups compared to healthy group. After the last ECT, TOS values were significantly lower compared to TOS values before ECT in major depression (p=0.004) and schizophrenia patients (p=0.004). TAS values after the first ECT were higher compared to values before ECT in major depression patients (p=0.004). After last ECT, OSI values were significantly lower compared to before ECT in schizophrenia patients (p=0.006).
Conclusion: As a result, it can be said that ECT did not increase oxidative stress. However, further studies with more patients are needed.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Barichello T / 2004 / No evidence for oxidative damage in the hippocampus after acute and chronic electroshock in rats / Brain Res 1014 : 177 ~ 183
Bitanihirwe BK / 2011 / Oxidative stress in schizophrenia : an integrated approach / Neurosci Biobehav Rev 35 : 878 ~ 893
Cumurcu BE / 2009 / Total antioxidant capacity and total oxidant status in patients with major depression : impact of antidepressant treatment / Psychiatry Clin Neurosci 63
Dakhale G / 2004 / Oxidative dam
Dal-Pizzol F / 2000 / Lipid peroxidation in hippocampus early and late after status epilepticus induced by pilocarpine or kainic acid in Wistar rats / Neurosci Lett 291 : 17
Bitanihirwe BK / 2011 / Oxidative stress in schizophrenia : an integrated approach / Neurosci Biobehav Rev 35 : 878 ~ 893
Cumurcu BE / 2009 / Total antioxidant capacity and total oxidant status in patients with major depression : impact of antidepressant treatment / Psychiatry Clin Neurosci 63
Dakhale G / 2004 / Oxidative dam
Dal-Pizzol F / 2000 / Lipid peroxidation in hippocampus early and late after status epilepticus induced by pilocarpine or kainic acid in Wistar rats / Neurosci Lett 291 : 17
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