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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 50 - 57 (8page)
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초록· 키워드
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ObjectivesThe usage of medicinal plants as natural antimicrobial agents has grown in many fields including dental medicine. The aim of this in vitro study was three-fold: (i) to determine the chemical compositions of the Ferula gummosa essential oil (FGEO), (ii) to compare the antimicrobial efficacy of the oil with sodium hypochlorite (NaOCl) and chlorhexidine (CHX), (iii) to assess the toxic behavior of FGEO in different concentrations compared to 5% NaOCl and 0.2% CHX.
Materials and MethodsGas chromatography/mass spectrometry (GC/MS) was used to determine the chemical compositions of the oil. The disk diffusion method and a broth micro-dilution susceptibility assay were exploited to assess the antimicrobial efficacy against Enterococcus faecalis, Staphylococcus aureus, Streptococcus mitis, and Candida albicans. The cytocompatibility of the FGEO was assessed on L929 fibroblasts, and compared to that of NaOCl and CHX.
ResultsTwenty-seven constituents were recognized in FGEO. The major component of the oil was β-pinene (51.83%). All three irrigants significantly inhibited the growth of all examined microorganisms compared to the negative control group. FGEO at 50 µg/mL was effective in lower concentration against Enterococcus faecalis than 5% NaOCl and 0.2% CHX, and was also more potent than 0.2% CHX against Candida albicans and Staphylococcus aureus. FGEO was a cytocompatible solution, and had significantly lower toxicity compared to 5% NaOCl and 0.2% CHX.
ConclusionsFGEO showed a promising biological potency as a root canal disinfectant. More investigations are required on the effectiveness of this oil on intracanal bacterial biofilms.
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참고문헌 (25)
참고문헌 신청
[학술지(정기간행물)] -
Adam R / 2007 / Identification of essential oil components by gas chromatography/mass Spectrometry / Allured publishing corporation
Badr AE / 2011 / A laboratory evaluation of the antibacterial and cytotoxic effect of Liquorice when used as root canal medicament / Int Endod J 44 : 51 ~ 58
Clinical and Laboratory Standards Institute / 2014 / Performance standards for antimicrobial susceptibility testing; twenty-fourth informational supplement
Eftekhar F / 2004 / Antibacterial activity of the essential oil from Ferula gummosa seed / Fitoterapia 75 : 758 ~ 759
Adam R / 2007 / Identification of essential oil components by gas chromatography/mass Spectrometry / Allured publishing corporation
Badr AE / 2011 / A laboratory evaluation of the antibacterial and cytotoxic effect of Liquorice when used as root canal medicament / Int Endod J 44 : 51 ~ 58
Clinical and Laboratory Standards Institute / 2014 / Performance standards for antimicrobial susceptibility testing; twenty-fourth informational supplement
Eftekhar F / 2004 / Antibacterial activity of the essential oil from Ferula gummosa seed / Fitoterapia 75 : 758 ~ 759
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