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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 375 - 383 (9page)
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Objectives : This study was performed to investigate the metabolic site of some medicinal herbs in the liver associated with CYP (Cytochrome P450).
Methods : Cytochrome P450 is the major enzymes involved in drug metabolism and bioactivation. CYP3A4 and CYP2D6, the major CYP isoforms in humans, catalyse the major proportion of drugs available on the market. Scintillation proximity assay (SPA) is often used in studies to identify compounds that inhibit CYP3A4 and CYP2D6. 28 herbal extracts and radioisotopes were attached competitively to SPA beads, and followed by measuring the remaining radioisotopes in the medium. Erythromycin and dexamethasone, inhibitors of CYP3A4 and CYP2D6, were used as controls respectively.
Results : Most of the 28 herbal extracts showed dose-dependent affinity to the CYP3A4 while some of the herbs showed affinity to the CYP2D6.
Conclusions : These results suggest that most of the 28 herbal extracts are metabolized safely in the liver, combined with CYP3A4 and CYP2D6.
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참고문헌 (30)
참고문헌 신청
Brattin WJ / 1985 / Pathological mechanisms in carbon tetrachloride hepatotoxicity / J Free Radic Biol Med 1 (1) : 27 ~ 38
Gonzalez FJ / 1988 / The molecular biology of cytochrome P450s / Pharmacol Rev 40 : 243 ~ 288
Guengerich FP / 1984 / Analysis and characterization of enezymes, In Principles and Methods of Toxicology / Raven Press : 1259 ~ 1313
Guengerich FP / 2003 / Cytochromes P450, drugs, and diseases / Mol Interv 3 (4) : 194 ~ 204
Hiroshi I / 2004 / Inhibition of human liver microsomal CYP3A4 and CYP2D6 by extracts from 78 herbal medicines / J Trad Med 21 : 42 ~ 50
Gonzalez FJ / 1988 / The molecular biology of cytochrome P450s / Pharmacol Rev 40 : 243 ~ 288
Guengerich FP / 1984 / Analysis and characterization of enezymes, In Principles and Methods of Toxicology / Raven Press : 1259 ~ 1313
Guengerich FP / 2003 / Cytochromes P450, drugs, and diseases / Mol Interv 3 (4) : 194 ~ 204
Hiroshi I / 2004 / Inhibition of human liver microsomal CYP3A4 and CYP2D6 by extracts from 78 herbal medicines / J Trad Med 21 : 42 ~ 50
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