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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 387 - 404 (18page)
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Objectives : This study was to observe anticancer and related immunomodulatory effects of Kwibi-tang extracts (KBTe) on non-small cell lung carcinoma (squamous epithelial carcinoma), NCI-H520, xenograft Balb/c nu-nu nude mice. Methods : Three different dosages of KBTe, 50, 100 and 200 mg/kg were orally administered once a day for 42 days from 11 days after tumor cell inoculation. Six groups, each of 8 mice per group were used in the present study. Changes on the body weight, tumor volume and weight, lymphatic organ (spleen and popliteal lymph node), serum interferon (IFN)-γ levels, splenocytes NK cell activity and peritoneal macrophage activities, splenic tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-10 contents were observed with tumor mass and lymphatic organ histopathology to detect anticancer and immunomodulatory effects. The results were compared with a potent cytotoxic anticancer agent, 5-FU (5-Fluorouracil) 30 mg/kg, intraperitoneal treatment (3-day intervals for 42 days, the optimal effective treatment regimes already confirmed). Results & Conclusions : This study suggest that over 50 mg/kg of KBTe showed favorable anticancer effects on the NCI-H520 cell xenograft with immunomodulatory effects. Although relatively lower anticancer effects were observed in KBTe 200 mg/kg treated mice as compared with 5-FU 30 mg/kg treated mice, there are no meaningful favorable immunomodulatory effects were observed after 5-FU treatment in the present study.
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참고문헌 (30)
참고문헌 신청
Clark BD / 1991 / Detection of interleukin 1 alpha and 1 beta in rabbit tissues during endotoxemia using sensitive radioimmunoassays / J Appl Physiol 71 : 2412 ~ 2418
Cooks T / 2009 / Local control of lung derived tumors by diffusing alpha-emitting atoms released from intratumoral wires loaded with radium-224 / Int J Radiat Oncol Biol Phy
Curran W / 2000 / Phase Ⅲ comparison of sequential vs comcurrent chemoradiation for patients (Pts) with unresected stage Ⅲ non-small cell lung cancer (NSCLC): Initial repor
Deveau AM / 2008 / Synthesis of diketopiperazine-based carboline homodimers and in vitro growth inhibition of human carcinomas / Bioorg Med Chem Lett 18 : 3522 ~ 3525
Hotchkiss RS / 1995 / Calcium antagonists decrease plasma and tissue concentrations of tumor necrosis factor-alpha, interleukin-1 beta, an
Cooks T / 2009 / Local control of lung derived tumors by diffusing alpha-emitting atoms released from intratumoral wires loaded with radium-224 / Int J Radiat Oncol Biol Phy
Curran W / 2000 / Phase Ⅲ comparison of sequential vs comcurrent chemoradiation for patients (Pts) with unresected stage Ⅲ non-small cell lung cancer (NSCLC): Initial repor
Deveau AM / 2008 / Synthesis of diketopiperazine-based carboline homodimers and in vitro growth inhibition of human carcinomas / Bioorg Med Chem Lett 18 : 3522 ~ 3525
Hotchkiss RS / 1995 / Calcium antagonists decrease plasma and tissue concentrations of tumor necrosis factor-alpha, interleukin-1 beta, an
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