지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives : This study aimed to evaluate the single oral dose toxicity of Seonpyejeongcheon-tang (SJT) in male and female Sprague-Dawley rats.
Methods : In this single oral toxicity study, rats were orally administrated in a single dose of 0 or 5,000 mg/kg SJT. There were 7 rats in each group. After single administration, mortality, clinical signs, body weight changes and gross pathological findings were observed for 14 days. Organ weight, clinical chemistry and hematology were tested after 14 days.
Results : There was no mortality or other clinical signs for 14 days. There were also no significant differences in body weight, organ weights, hematological and serum chemical parameters between the SJT and control groups. Conclusions : The results obtained in this study suggest that the 50% lethal dose of SJT is over 5,000 mg/kg, so this finding can be expected to provide scientific evidence for the safety of SJT.
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참고문헌 (26)
참고문헌 신청
Favreau JT / 2002 / Severe hepatotoxicity associated with the dietary supplement LipoKinetix / Ann Intern Med 136 (8) : 590 ~ 595
Irwin RS / 1977 / Cough. A comprehensive review / Arch Intern Med 137 : 1186 ~ 1191
Matsumoto H / 2006 / Prognosis of cough variant asthma: a retrospective analysis / J Asthma 43 (2) : 131 ~ 135
McGarvey LP / 1998 / Evaluation and outcome of patients with chronic non-productive cough using a comprehensive diagnostic protocol / Thorax 53 (9) : 738 ~ 743
OECD / 2001 / OECD guideline for testing of chemicals No. 423 Acute oral toxicity-Acute classic method
Irwin RS / 1977 / Cough. A comprehensive review / Arch Intern Med 137 : 1186 ~ 1191
Matsumoto H / 2006 / Prognosis of cough variant asthma: a retrospective analysis / J Asthma 43 (2) : 131 ~ 135
McGarvey LP / 1998 / Evaluation and outcome of patients with chronic non-productive cough using a comprehensive diagnostic protocol / Thorax 53 (9) : 738 ~ 743
OECD / 2001 / OECD guideline for testing of chemicals No. 423 Acute oral toxicity-Acute classic method
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