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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 487 - 496 (10page)
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초록· 키워드
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Objectives : The aim of this study was to investigate the hepatoprotective effect of Soshiho-tang (SSH) in mouse primary liver cells against hydrogen peroxide (H2O2)-induced oxidative stress. We also elucidated the molecular mechanism of hepatoprotective effect by SSH.
Methods : Cell viability, level of ALT, AST and LDH, intracellular ROS level, mRNA expression and activity of antioxidant enzymes were used to evaluate hepatoprotection of SSH against H2O2. Target gene expressions were analyzed by real-time PCR.
Results : Pre-treatment with SSH for 1 hour prevented cytotoxicity against H2O2. H2O2-induced ROS level decreased under SSH pre-treatment. mRNA expression of GPx and SOD increased in SSH-treated cells. In addition, HSP72 and HSP40 gene expression were elevated under SSH-treatment.
Conclusions : These results indicate that SSH protects mouse primary liver cells from H2O2-induced oxidative injury. This hepatoprotective activity of SSH is mediated by decreasing intracellular ROS and increasing antioxidant enzyme expression (GPx and SOD) and stress response protein (HSP72 and HSP40).
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참고문헌 (27)
참고문헌 신청
Sterrenberg JN / 2011 / Human DNAJ in cancer and stem cells / Cancer Lett 312(2):129~142
윤길숙 / 2006 / 신세포암종에서 Heat Shock Protein 27의 발현과 세포자멸사에 대한 연구 / The Korean Journal of Pathology 40(1):39~45
Amagaya S / 1986 / Inhibitory action of shosaikoto and daisaikoto(traditional Chinese medicine) on collagen-induced platelet aggregation and prostaglandin biosynthesis / Plan
Amagaya S / 1988 / Effect of Syo-saiko-to and Dai-saiko-to on carbon tetrachlorideinduced hepatic injury in rats / J Med Pharm Soc Wakan Yaku 5 : 129 ~ 136
Amagaya S / 1988 / Effect of Syo-saiko-to on liver regeneration in partially hepatectomized rats / J Med Pharm Soc Wakan Yaku 5 : 137 ~ 145
윤길숙 / 2006 / 신세포암종에서 Heat Shock Protein 27의 발현과 세포자멸사에 대한 연구 / The Korean Journal of Pathology 40(1):39~45
Amagaya S / 1986 / Inhibitory action of shosaikoto and daisaikoto(traditional Chinese medicine) on collagen-induced platelet aggregation and prostaglandin biosynthesis / Plan
Amagaya S / 1988 / Effect of Syo-saiko-to and Dai-saiko-to on carbon tetrachlorideinduced hepatic injury in rats / J Med Pharm Soc Wakan Yaku 5 : 129 ~ 136
Amagaya S / 1988 / Effect of Syo-saiko-to on liver regeneration in partially hepatectomized rats / J Med Pharm Soc Wakan Yaku 5 : 137 ~ 145
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