지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 126 - 144 (19page)
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초록· 키워드
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Background : Peripheral nerves more rapidly recover than central nerves. However, it has been known that the degree of reaction of axons of peripheral nerves is affected by distinctive characteristics of axons and environmental factors near the axons. Taxol is a widely used medicine as for ovarian, breast, lung and gastric cancer. However it causes patients difficulties under treatment due to its toxic and side effects, which include persistent pain.
Objectives : This study reviewed how SJT extract in vitro and in vivo affects nerve tissues of a sciatic nerve damaged by Taxol. It also studied how SJT extract in vivo affects axons of the sciatic nerve after the sciatic nerve was damaged by pressing.
Methods : After vehicle, Taxol, and Taxol plus SJT were treated respectively for tissue of the sciatic nerve in vitro and then tissues were observed using Neurofilament 200, Hoechst, β-tubulin, S100β, caspase-3 and anti-cdc2.
SJT was also oral medicated by injecting Taxol into the sciatic nerve of in vivo rats. Tissues of the sciatic nerve and axons of DRG sensory nerves were then observed using Neurofilament 200, Hoechst, β-tubulin, S100β, caspase-3 and p-Erk1/2.
After inflicting pressing damage to the sciatic nerve of in vivo rats, tissues of the sciatic nerve and DRG sensory nerve were observed using Neurofilament 200, Hoechst, S100β, caspase-3, anti-cdc2, phospho-vimentin, β1-integrin, Dil reverse tracking and p-Erk1/2.
Results : The group of in vitro Taxol plus SJT treatment had meaningful effects after sciatic nerve tissue was damaged by Taxol. The group of in vivo SJT treatment had effects of regenerating Schwann cells and axons which were damaged by Taxol treatment. The group of in vivo SJT had effects of regenerating axons in damaged areas after the sciatic nerve was damaged by pressing, and also had variations of distribution in Schwann cells at DRG sensory nerves and axons.
Conclusions : This study confirmed that SJT treatment is effective for growth of axons in the sciatic nerve tissues and improvement of Schwann cells after axons of the sciatic nerve tissues was damaged. After tissues of sciatic nerve was damaged by pressing in vivo, SJT treatment had effects on promoting regeneration of axon in the damaged area and reactional capabilities in axons of DRG sensory nerves.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Al-Majed AA / 2000 / Brief electrical stimulation promotes the speed and accuracy of motor axonal regeneration / J Neurosci 20 (7) : 2602 ~ 2608
Ambron RT / 1996 / Priming events and retrograde injury signals. A new perspective on the cellular and molecular biology of nerve regeneration / Mol Neurobiol 13 : 61 ~ 79
Banker G / 1991 / Culturing Nerve Cells / MIT Press : 453 ~
Bhatheja K / 2006 / Schwann cells: Origins and role in axonal maintenance and regeneration / Int J Biochem Cell Biol 38 (12) : 1995 ~ 1999
Bjartmar C / 1999 / Axonal pathology in myelin disorders / J Neurocytol 28 (4) : 383 ~ 395
Ambron RT / 1996 / Priming events and retrograde injury signals. A new perspective on the cellular and molecular biology of nerve regeneration / Mol Neurobiol 13 : 61 ~ 79
Banker G / 1991 / Culturing Nerve Cells / MIT Press : 453 ~
Bhatheja K / 2006 / Schwann cells: Origins and role in axonal maintenance and regeneration / Int J Biochem Cell Biol 38 (12) : 1995 ~ 1999
Bjartmar C / 1999 / Axonal pathology in myelin disorders / J Neurocytol 28 (4) : 383 ~ 395
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