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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 155 - 158 (4page)
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초록· 키워드
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The objective of this study was to evaluate the antiviral activity of Phaeophyta extracts against feline calicivirus (FCV), used as a norovirus surrogate. A bioassay-guided cytotoxicity and virus infectivity assay revealed that methanolic extracts of Phaeophyta possessed significant antiviral activity against FCV. Among them, Eisenia bicyclis extract exhibited the highest antiviral activity against FCV. The 50% effective concentration of the extract (EC50) inhibiting FCV viral replication by 50% was 80 μg/ mL.
The extract also showed the highest selectivity index, calculated from the ratio of the median cellular cytotoxicity concentration (CC50) and EC50, indicating antiviral efficacy against FCV. In addition, significant interruption of FCV infection was observed by pretreatment of host Crandall-Reese feline kidney cells with the E. bicyclis extract (200 μg/mL) prior to virus infection, in a dosedependent manner.
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참고문헌 (20)
참고문헌 신청
Arunkumar K / 2012 / Seasonal influence on bioactivity of seaweeds against plant pathogenic bacteria Xanthomonas axonopodis pv. Citri (Hasse) Vauterin et al / Afr J Microbiol
Bidawid S / 2003 / A feline kidney cell line-based plaque assay for feline calicivirus, a surrogate for Norwalk virus / J Virol Methods 107 : 163 ~ 167
Carlucci MJ / 2004 / Protective effect of a natural carrageenan on genital herpes simplex virus infection in mice / Antiviral Res 64 : 137 ~ 141
Centers for Disease Control and Prevention / / Updated norovirus outbreak management and disease prevention guidelines
Cheek JE / 2002 / Norwalk-like virus-associated gastroenteritis in a large, high-density encampament: Virginia, July 2001 / MMWR Morb Mortal Wkly Rep 51 : 661 ~ 663
Bidawid S / 2003 / A feline kidney cell line-based plaque assay for feline calicivirus, a surrogate for Norwalk virus / J Virol Methods 107 : 163 ~ 167
Carlucci MJ / 2004 / Protective effect of a natural carrageenan on genital herpes simplex virus infection in mice / Antiviral Res 64 : 137 ~ 141
Centers for Disease Control and Prevention / / Updated norovirus outbreak management and disease prevention guidelines
Cheek JE / 2002 / Norwalk-like virus-associated gastroenteritis in a large, high-density encampament: Virginia, July 2001 / MMWR Morb Mortal Wkly Rep 51 : 661 ~ 663
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