지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 5 - 11 (7page)
이용수
초록· 키워드
오류제보하기
Background: We conducted research to determine the effect of the weight on left ventricular (LV) diastolic function in Asians,who are at greater risk of cardiovascular events compared to individuals from Western countries with similar body mass indices(BMIs).
Methods: We studied 543 participants with structurally normal hearts and normal ejection fractions. Participants were classifiedas normal-weight (BMI < 23.0 kg/m2), overweight (BMI 23.0–27.4 kg/m2), or obese (BMI ≥ 27.5 kg/m2). Peak E velocity,peak A velocity, and E’ velocity were measured and E/E’ was calculated.
Results: Overweight participants had lower E than normal-weight participants (p = 0.001). E’ velocities in overweight andobese participants were less than those in normal weight participants (both p < 0.001). The E/E’ ratio in obese participants washigher compared to the value in normal-weight participants (p < 0.001) and overweight participants (p = 0.025). BMI was associatedwith E (R = -0.108), A (R = 0.123), E’ (R = -0.229), and E/E’ ratio (R = 0.138) (all p < 0.05). In multivariate analyses,BMI was independently associated with higher A, lower E’, and higher E/E’. The risk of diastolic dysfunction was significantlyhigher among overweight [adjusted odds ratio: 2.088; 95% confidence interval (CI): 1.348–3.235; p = 0.001] and obese participants(adjusted odds ratio: 5.910; 95% CI: 2.871–12.162; p < 0.001) compared to normal-weight participants.
Conclusion: Obesity and overweight independently predicted diastolic dysfunction. An optimal body weight lower than theuniversal cut-off is reasonable for preventing LV heart failure in Asians.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Alpert MA / 2001 / Obesity cardiomyopathy: pathophysiology and evolution of the clinical syndrome / Am J Med Sci 321 : 225 ~ 236
Chang CJ / 2003 / Low body mass index but high percent body fat in Taiwanese subjects: implications of obesity cutoffs / Int J Obes Relat Metab Disord 27 : 253 ~ 259
Chiu HC / 2001 / A novel mouse model of lipotoxic cardiomyopathy / J Clin Invest 107 : 813 ~ 822
Deurenberg P / 2002 / Asians are different from Caucasians and from each other in their body mass index/body fat per cent relationship / Obes Rev 3 : 141 ~ 146
Devereux RB / 1986 / Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings / Am J Cardiol 57 : 450 ~ 458
Chang CJ / 2003 / Low body mass index but high percent body fat in Taiwanese subjects: implications of obesity cutoffs / Int J Obes Relat Metab Disord 27 : 253 ~ 259
Chiu HC / 2001 / A novel mouse model of lipotoxic cardiomyopathy / J Clin Invest 107 : 813 ~ 822
Deurenberg P / 2002 / Asians are different from Caucasians and from each other in their body mass index/body fat per cent relationship / Obes Rev 3 : 141 ~ 146
Devereux RB / 1986 / Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings / Am J Cardiol 57 : 450 ~ 458
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