후두의 양성, 전암성, 악성 상피 병변에서Melanoma Antigen Gene(MAGE) 발현의 차이

김정규; 박규욱; 김기영; 전창호; 손진호; 박준식

추천

검색

자료유형: 학술저널

저자정보: 김정규 박규욱 김기영 전창호 손진호 박준식

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제50권 제4호

발행연도: 2007.1

수록면: 341 - 345 (5page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background and Objectives：The degree of dysplasia of premalignant lesion of the larynx is related to malignant transfor-mation. However, no single molecular marker that could be used to predict malignant transformation has been identified. Melanoma antigen genes (MAGE), which are expressed in malignant tissues but not in normal tissues, might provide such a marker. So, we investigated MAGE expressions in the various epithelial lesions of the larynx. Subjects and Method：Nested RT-PCR with MAGE common primers were performed to detect the expression of MAGE A genes in fresh frozen tissues obtained from laryngeal lesions (34 benign, 20 premalignant, 22 malignant epitheliums) and 12 normal oropharyngeal epitheliums. Results：The expression of MAGE was positive in 12 (35.3%) of benign, 10 (50% ) of premalignant, 18 (81.8%) of malignant laryngeal epithelium and 1 (8.5%) of normal epithelium. These expressions were different with statistic significance (p= 0.003) between benign, premalignant and malignant laryngeal epithelium. Conclusion：The MAGE A expression could be utilized as a biomar-ker to predict malignant transformation of laryngeal epithelium. (Korean J Otolaryngol 2007 ;50 :341-5)

#MAGE 유전자·전암성 병변·종양 표지자·후두. #MAGE· Precancerous condition· Tumor markers· Larynx.

참고문헌 (20)

참고문헌 신청

/ 1995 / Expression of the MAGE gene family in human head-and-neck squamous-cell carcinomas 64 (5) : 304 ~ 308

/ 1995 / Laryngeal dysplasia: Epidemiology and treatment outcome 104 (8) : 596 ~ 602

/ 1996 / Expression of the MAGE-1, -2, -3, -4 and -6 genes in non-squamous cell carcinoma lesions of the head and neck 116 (4) : 633 ~ 639

/ 1996 / High frequency of the MAGE-1 gene expression in hepatocellular carcinoma 24 (6) : 1437 ~ 1440

/ 1998 / Expression of MAGE 3 gene product in squamous cell carcinoma of the head and neck 41 (10) : 1296 ~ 1303

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!