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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제50권 제4호
발행연도
2007.1
수록면
335 - 340 (6page)

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Background and Objectives:Although the cause of the malignant lymphoma has not been understood entirely, viruses and oncogenes have been implicated as probable causative factors. Particularly, Epstein-Barr virus (EBV), the over-expression of bcl-2 and the mutant p53 seem to be closely related to lymphomatogenesis. The purpose of this study was to investigate the relation-ship between EBV, bcl-2 and p53 proteins in the development of human extranodal malignant lymphoma in the head and neck. Subjects and Method:Specimens were obtained from 40 patients diagnosed as the extranodal malignant lymphoma in the head and neck region. Paraffin-embedded tumor tissues were analyzed by in situ hybridization for Epstein-Barr virus encoded RNA (EBER) and by immunohistochemical technique for bcl-2 and p53 proteins. Results:In EBER and bcl-2 protein-positive group, (85.7%) and the peripheral T cell lymphoma unspecified large cell type (83.3%) were identified significantly in the p53 protein positive group (p<0.05). Expression rate of EBER, bcl-2 and p53 protein were 50%, 42.5% and 53.5%, respectively. In the EBER-positive group (20 cases), bcl-2 protein was detected in 9 cases (45.0%) and p53 protein in 11 cases (55.0%). In bcl-2 protein-positive group (17 case), p53 protein was detected in 9 cases (52.9%). There were no significant diference among these data (p>0.05). Conclusion:These results suggest that EBV, bcl-2 and p53 protein play a role in the tumorigenesis of the human extranodal malignant lymphoma, independently. (Korean J Otolaryngol 2007 ;50 :335-40)

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