지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 813 - 818 (6page)
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초록· 키워드
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p21-activated kinases (PAKs) are a family of serine/threonine protein kinases comprised of six isoform (PAK1-6), all of which are direct targets of the small GTPases Rac and Cdc42. PAKs have recently been shown to regulate various cellular activities, including cell motility, survival and proliferation, the organization and function of cytoskeleton and extracellular matrix, transcription and translation. PAKs are overexpressed or hyperactivated in several human tumor, such as breast cancer, gastric cancer, ovarian cancer etc., which makes them an attractive new therapeutic targets. Thus, there has been considerable interest in the development of inhibitors to the PAKs, as biological markers and leads for the development of therapeutics.
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참고문헌 (24)
참고문헌 신청
Bagrodia S / 1998 / A novel regulator of p21-activated kinases / J Biol Chem 273 (37) : 23633 ~ 23636
Balasenthil S / 2004 / p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells / J Biol Chem 279 (2) : 1422 ~ 1428
Beeser A / 2005 / Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors / J Biol Chem 280 (44) : 36609 ~ 36615
Chong C / 2001 / The mechanism of PAK activation.Autophosphorylation events in both regulatory and kinase domains control activity / J Biol Chem 276 (20) : 17347 ~ 17353
Dan C / 2002 / PAK5,a new brain-specific kinase,promotes neurite outgrowth in N1E-115 cells / Mol Cell Biol 22 (2) : 567 ~ 577
Balasenthil S / 2004 / p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells / J Biol Chem 279 (2) : 1422 ~ 1428
Beeser A / 2005 / Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors / J Biol Chem 280 (44) : 36609 ~ 36615
Chong C / 2001 / The mechanism of PAK activation.Autophosphorylation events in both regulatory and kinase domains control activity / J Biol Chem 276 (20) : 17347 ~ 17353
Dan C / 2002 / PAK5,a new brain-specific kinase,promotes neurite outgrowth in N1E-115 cells / Mol Cell Biol 22 (2) : 567 ~ 577
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