지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 155 - 160 (6page)
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초록· 키워드
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Background and Objectives The phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) taste sensitivity varies among individuals. Recently, it is reported that PROP taste responsiveness is associated with carbonic anhydrase 6 (CA6) gene polymorphism. The CA6 gene, a zinc metalloprotein in human saliva, is affected in taste function and might be correlated with gustatory diversity. The aim of this study was to examine whether PTC taste sensitivity and taste disorder is associated with the CA6 gene polymorphism rs2274327 (C/T), rs2274328 (A/C), and rs2274333 (A/G).
Subjects and Method A total of 217 healthy normal subjects were recruited as controls, and 50 taste disorder patients were recruited as experimental group. The polymorphisms of CA6 gene were genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis. All statistical analyses were calculated using the statistical package for the social science software. Haplotypes were estimated by Haploveiw and the PHASE programs.
Results The CA6 gene polymorphisms showed association with taste disorder but not with PTC sensitivity (taster/nontaster). The number of control subjects carrying AA genotype of single nucleotide polymorphism rs2274328 (A/C) in the CA6 gene was higher than the number of the subjects with taste disorder (p=0.048). However, there was no association between controls and taste disorder subjects in the haplotype analysis.
Conclusion These data suggest that the CA6 gene polymorphism rs2274328 could affect taste function impairment in patients with taste disorder. This observation requires a further functional study of gustin protein to clarify the association of the CA6 gene polymorphisms with the taste disorder and sensitivity.
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참고문헌 (25)
참고문헌 신청
Bufe B / 2005 / The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception / Curr Biol 15 (4) : 322 ~ 327
CaloC / 2011 / Polymorphisms in TAS2R38 and the taste bud trophic factor, gustin gene co-operate in modulating PROP taste phenotype / Physiol Behav 104 (5) : 1065 ~ 1071
Chaudhari N / 2010 / The cell biology of taste / J Cell Biol 190 (3) : 285 ~ 296
Fernley RT / 1995 / Radioimmunoassay for salivary carbonic anhydrase in human parotid saliva / Arch Oral Biol 40 (6) : 567 ~ 569
Gilbertson TA / 2000 / The molecular physiology of taste transduction / Curr Opin Neurobiol 10 (4) : 519 ~ 527
CaloC / 2011 / Polymorphisms in TAS2R38 and the taste bud trophic factor, gustin gene co-operate in modulating PROP taste phenotype / Physiol Behav 104 (5) : 1065 ~ 1071
Chaudhari N / 2010 / The cell biology of taste / J Cell Biol 190 (3) : 285 ~ 296
Fernley RT / 1995 / Radioimmunoassay for salivary carbonic anhydrase in human parotid saliva / Arch Oral Biol 40 (6) : 567 ~ 569
Gilbertson TA / 2000 / The molecular physiology of taste transduction / Curr Opin Neurobiol 10 (4) : 519 ~ 527
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