Comparison of Patient Satisfaction between Subcutaneous Immunotherapy and Sublingual Immunotherapy in Allergic Rhinitis

Nopphawan Longchuphon; 김수진; 이건희; 조중생; 김성완

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자료유형: 학술저널

저자정보: Nopphawan Longchuphon 김수진 이건희 조중생 김성완

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제59권 제2호

발행연도: 2016.1

수록면: 120 - 124 (5page)

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Background and Objectives Comparative clinical studies of sublingual and subcutaneous treatments have yielded heterogeneous results. In this study, we compared clinical outcomes in patients allergic to house dust mites (HDMs) that received at least 1 year of subcutaneous immunotherapy (SCIT) or sublingual immunotherapy (SLIT). Subjects and Method The present study included 120 patients with HDM allergic rhinitis, 54 patients in the SCIT group and 66 patients in the SLIT group. Each patient was asked to answer a set of questionnaire before starting immunotherapy. The questionnaires included the rhinoconjunctivitis quality of life questionnaire (RQLQ) and a patient satisfaction questionnaire. The patients were asked to answer the questions after undergoing at least 1 year of immunotherapy. Results RQLQ scores collected after immunotherapy in both SCIT and SLIT groups were decreased significantly. However, the SCIT group had a significantly higher decrease in RQLQ scores for non-nose/eye symptoms than the SLIT group (p-value=0.015). There were no differences in other satisfaction scores between the two groups. SCIT improved clinical symptoms faster than SLIT did within 6 months and 1 year (p-value=0.011, p-value=0.045 respectively). Conclusion SCIT is more effective than SLIT in improving non-nose/eye symptoms in patients with allergic rhinitis. SCIT may relieve the symptoms faster than SLIT. Korean J Otorhinolaryngol-Head Neck Surg 2016;59(2):120-4

#Allergic rhinitis ㆍImmunotherapy ㆍPatient satisfaction ㆍ Rhinoconjunctivitis quality of life questionnaire.

참고문헌 (13)

참고문헌 신청

Akdis CA / 2006 / Allergy and hypersensitivity: mechanisms of allergic disease / Curr Opin Immunol 18(6):718~726

Brozek JL / 2010 / Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision / J Allergy Clin Immunol 126(3):466~476

Akdis CA / 2011 / Mechanisms of allergen-specific immunotherapy / J Allergy Clin Immunol 127(1):18~27

Casale TB / 2014 / Immunotherapy: what lies beyond / J Allergy Clin Immunol 133(3):612~619

Calderón MA / 2012 / Sublingual allergen immunotherapy: mode of action and its relationship with the safety profile / Allergy 67(3):302~311

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