Use of 18F-Fluorodeoxyglucose Positron Emission  Tomography in Patients with Rare Head and Neck  Cancers

노종렬; 문병재; Jae Seung Kim; Jeong Hyun Lee; Kyung-Ja Cho; 최승호; 남순열; 이봉재; 김상윤

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자료유형: 학술저널

저자정보: 노종렬 문병재 Jae Seung Kim Jeong Hyun Lee Kyung-Ja Cho 최승호 남순열 이봉재 김상윤

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제1권 제2호

발행연도: 2008.1

수록면: 103 - 109 (7page)

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2008

Use of 18F-Fluorodeoxyglucose Positron Emission Tomography in Patients with Rare Head and Neck Cancers

노종렬 , 문병재 , Jae Seung Kim 외 6명 Clinical and Experimental Otorhinolaryngology 2008.01 학술저널

2006

Clinical Significance of Intrathoracic Lesions Detected by $^{18}F$-Fluorodeoxyglucose Positron Emission Tomography in the Management of Patients with Head and Neck Cancer

노종렬 , 유창환 , 김재승 외 4명 대한두경부종양학회 학술대회 2006.01 학술대회자료

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Objectives. The clinical utility of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) has been demonstrated in major head and neck cancers (HNCs) but is unclear in rare HNCs. We therefore evaluated FDG PET in the management of patients with rare HNCs. Methods. FDG PET and CT/MRI scanning were performed at the initial staging and/or the follow-up in 24 patients with rare HNCs, 10 with melanoma, 9 with sarcoma, 3 with olfactory neuroblastomas, and 2 with basal cell carcinoma. The diagnostic accuracy of CT and FDG PET for detecting primary tumors and metastases were compared with a histopathologic reference. The association between the PET results and the clinicopathologic parameters predicting tumor invasion, histologic grade and disease-free survival (DFS), was assessed. Results. The overall accuracies of FDG PET and CT/MRI were 92% and 79%, respectively, for detecting primary tumors and 91% and 74%, respectively, for nodal metastases, but the differences were not significant due to the small number of patients. The sensitivity and specificity of FDG PET for detecting distant metastases and second primary tumors were 100% and 87%, respectively. Follow-up FDG PET correctly diagnosed locoregional recurrence in all 12 patients, as shown by biopsy, and distant metastases in 6 patients. However, thickness of melanoma, histologic grade of sarcoma, and DFS were not associated with tumor FDG uptake. Conclusion. FDG PET may be useful for staging, posttreatment monitoring, and detection of distant metastases and second primary tumors in patients with rare HNCs.

#Head and neck neoplasms #Fluorodeoxyglucose #Positron-emission tomography #Neoplasm staging #Surveillance

참고문헌 (24)

참고문헌 신청

Adams S / 1998 / Prospective comparison of 18F-FDG PET with conventional imaging modalities (CT, MRI, US) in lymph node staging of head and neck cancer / Eur J Nucl Med 25 (9

American Joint Committee on Cancer / 2002 / AJCC Cancer Staging Manual / Springer-Verlag : 187 ~ 220

Bui CD / 2003 / Diagnostic accuracy of 2-[fluorine-18]fluro-2-deoxy-D-glucose positron emission tomography imaging in nonsquamous tumors of the head and neck / Invest Radiol

Clark PB / 2006 / Futility of fluorodeoxyglucose F 18 positron emission tomography in initial evaluation of patients with T2 to T4 melanoma / Arch Surg 141 (3) : 284 ~ 288

Fosko SW / 2003 / Positron emission tomography for basal cell carcinoma of the head and neck / Arch Dermatol 139 (9) : 1141 ~ 1146

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